Division of Child and Adolescent Psychiatry, University of California, Los Angeles, Los Angeles, CA, United States of America.
Division of Clinical Therapeutics, New York State Psychiatric Institute, New York, NY, United States of America; Department of Psychiatry, Columbia University Medical Center, New York, NY, United States of America.
Compr Psychiatry. 2018 Nov;87:46-52. doi: 10.1016/j.comppsych.2018.08.011. Epub 2018 Aug 25.
Pathological Skin Picking (PSP) may begin at any age, but the most common age of onset is during adolescence. Age of onset is a potentially useful clinical marker to delineate subtypes of psychiatric disorders. The present study sought to examine empirically defined age of onset groups in adults with PSP and assess whether groups differed on clinical characteristics.
Participants were 701 adult respondents to an internet survey, who endorsed recurrent skin picking with tissue damage and impairment. Latent profile analysis (LPA) was conducted to identify subtypes of PSP based on age of onset. Then subgroups were compared on demographic and clinical characteristics.
The best fitting LPA model was a two-class solution comprised of a large group with average age of onset in adolescence (n = 650; 92.9% of the sample; Mean age of onset = 13.6 years) and a small group with average onset in middle adulthood (n = 50; 7.1% of the sample; Mean age of onset = 42.8 years). Relative to the early onset group, the late onset group reported significantly less focused picking, less skin picking-related impairment, lower rates of co-occurring body-focused repetitive behaviors, and trends towards reduced family history of PSP. Individuals in the late onset group also reported increased rates of comorbid depression, anxiety and posttraumatic stress disorder, and were more likely to report that initial picking onset seemed related to or followed depression/anxiety and physical illness.
Findings suggest the presence of two distinct PSP age of onset groups: (1) an early onset group with average onset in adolescence, clinical characteristics suggestive of greater picking-related burden and familiality, and a profile more representative of the general PSP population; and (2) a late onset group with average onset in middle adulthood, increased co-occurring affective and trauma conditions, and initial onset associated with or following other mental health and physical problems. Future replication is needed to assess the validity and clinical utility of these subgroups.
病理性皮肤搔抓(PSP)可能在任何年龄开始,但最常见的发病年龄是在青春期。发病年龄是划分精神障碍亚型的一个潜在有用的临床标志。本研究旨在通过对患有 PSP 的成年人进行实证定义的发病年龄组研究,评估这些组在临床特征上是否存在差异。
参与者为参加互联网调查的 701 名成年应答者,他们反复出现伴有组织损伤和功能障碍的皮肤搔抓。采用潜在剖面分析(LPA)根据发病年龄确定 PSP 的亚型。然后比较亚组在人口统计学和临床特征上的差异。
最佳拟合的 LPA 模型是一个由大组组成的两群模型,大组的平均发病年龄在青春期(n=650;样本的 92.9%;平均发病年龄=13.6 岁),以及一个小组的平均发病年龄在中年(n=50;样本的 7.1%;平均发病年龄=42.8 岁)。与早期发病组相比,晚期发病组报告的专注性搔抓明显较少,与皮肤搔抓相关的损伤较少,共发性躯体聚焦性重复行为的发生率较低,且家族性 PSP 病史减少。晚期发病组的个体还报告了更高的共患抑郁、焦虑和创伤后应激障碍的发生率,并且更有可能报告初始搔抓发病似乎与抑郁/焦虑和身体疾病有关或紧随其后。
研究结果表明存在两种不同的 PSP 发病年龄组:(1)一个发病年龄在青春期的早发性组,具有更大的搔抓相关负担和家族性特征,以及更具代表性的一般 PSP 人群特征;(2)一个发病年龄在中年的晚发性组,共患的情感和创伤性疾病发生率较高,以及与其他心理健康和身体问题相关或紧随其后的初始发病。未来需要进一步的复制研究来评估这些亚组的有效性和临床实用性。