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失眠的发病年龄:一项潜在类别分析。

Age of Onset in Insomnia: A Latent Profile Analysis.

作者信息

Ricketts Emily J, Kircanski Katharina, Joyce Daniel S, Rissman Ariel J, Ottenberg Juliet, Soehner Adriane M

机构信息

Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, Los Angeles, California, USA.

Department of Psychology, University of Southern California, Los Angeles, California, USA.

出版信息

J Sleep Res. 2025 Jun 23:e70103. doi: 10.1111/jsr.70103.

Abstract

Research has sought to understand insomnia through identification of subtypes, yet age of onset has received limited focused empirical attention. This investigation aimed to detect clinically distinct age of insomnia onset subgroups utilising latent profile analysis (LPA). Participants were 618 adults, aged 18-71 years (M = 28.94, SD = 11.06), with insomnia. Participants completed a survey assessing insomnia natural history and causal attributions; sleep disturbance and impairment; pre-sleep arousal and threat monitoring; stress, mental and physical health; and social functioning. LPA was performed on age of insomnia onset. Binary logistic regression analyses were performed to evaluate associations between clinical measures and early versus late onset insomnia with statistical adjustment for chronological age and sex. Results showed a two-class model (Class 1: n = 547, 88.5%, M = 19.21 years, range = 0-34 years; Class 2: n = 71, 11.5%, M = 43.49 years, range = 35-68 years) was optimal for forming insomnia age of onset subgroups. Bodily arousal and developmental (e.g., childhood experiences, traumatic events) contributors to insomnia onset, greater overall and cognitive pre-sleep arousal, later bedtime and rise time, greater depressive symptoms, and endorsement of lifetime major depressive disorder, migraine, and arthritis were significant indicators of early onset insomnia subgroup membership. Hormonal contributors (e.g., ageing, menopause) to insomnia onset and maintenance, and more positive global mental health were significant indicators of late onset insomnia subgroup membership. Findings suggest the relevance of mindfulness-based, acceptance-based, and trauma-focused adaptations of cognitive-behavioural therapy for early onset insomnia, and management of ageing-related hormonal changes for late onset insomnia.

摘要

研究试图通过识别亚型来理解失眠症,但失眠症的发病年龄受到的实证关注有限。本研究旨在利用潜在剖面分析(LPA)来检测临床上不同的失眠症发病年龄亚组。研究对象为618名年龄在18 - 71岁(M = 28.94,SD = 11.06)的失眠成年人。参与者完成了一项调查,评估失眠的自然史和因果归因;睡眠障碍和损害;睡前觉醒和威胁监测;压力、心理和身体健康;以及社会功能。对失眠症发病年龄进行了潜在剖面分析。进行了二元逻辑回归分析,以评估临床指标与早发性和晚发性失眠症之间的关联,并对年龄和性别进行统计调整。结果显示,两类模型(第1组:n = 547,88.5%,M = 19.21岁,范围 = 0 - 34岁;第2组:n = 71,11.5%,M = 43.49岁,范围 = 35 - 68岁)最适合形成失眠症发病年龄亚组。身体觉醒和发育因素(如童年经历、创伤事件)导致失眠症发作、更高的总体和认知性睡前觉醒、更晚的就寝时间和起床时间、更严重的抑郁症状以及曾患重度抑郁症、偏头痛和关节炎是早发性失眠亚组成员的重要指标。激素因素(如衰老、更年期)导致失眠症发作和维持,以及更积极的总体心理健康是晚发性失眠亚组成员的重要指标。研究结果表明,基于正念、接纳和聚焦创伤的认知行为疗法对早发性失眠症具有相关性,而针对晚发性失眠症则需管理与衰老相关的激素变化。

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