Bi Ying-Fei, Mao Jing-Yuan, Wang Xian-Liang, Hou Ya-Zhu, Zhao Zhi-Qiang, Ge Yong-Bin, Yu Xiao-Han
First Teaching Hospital Affiliated to Tianjin University of TCM Tianjin University of TCM, Tianjin, China.
Medicine (Baltimore). 2018 Sep;97(36):e12097. doi: 10.1097/MD.0000000000012097.
Chronic stable coronary artery disease (SCAD) is a general term for all kinds of coronary artery disease (CAD), which includes patients with chronic stable angina, old myocardial infarctions, and also stable condition after revascularization (i.e., percutaneous coronary intervention, coronary artery bypass graft). According to 2012 AHA/ACC guidelines, the objective of the treatment for SCAD is to maintain or recover patients' exercise tolerance, quality of life, and avoid complication like heart failure, so as to decrease mortality, eliminate symptoms, and avoid adverse reactions. Traditional Chinese medicine (TCM) has 2000 years of history in managing CAD and has its advantages in improving quality of life. Using scientific method to evaluate, demonstrate, and conclude the clinical curative effect of TCM is an extremely important task for both TCM and integrative Chinese and Western medicine in the treatment of CAD.
This research is to collect real effective cases from authoritative TCM cardiologists' clinic, so as to build a TCM diagnosis and treatment information database that involve 2000 patients from 32 different top-3 hospitals of china. The primary outcome includes EuroQol-5 Dimensions and Four diagnostic method of TCM, and secondary outcome includes angina score and some laboratory indexes like electrocardiograms, dynamic electrocardiogram, ultrasonic cardiogram, and treadmill exercise testing. This research uses SPSS17.0. to do the statistical analysis application. Enumeration data use χ test and measurement data which fit normality test use t test. The analysis of drugs usage in different diseases, different syndromes and different life quality effect will use principal component analysis, factorial analysis, clustering analysis. and point mutual information method, and so on.
This research, based on past syndromes research and real clinical effective chronic SCAD cases, aim to build a TCM diagnosis and treatment information database.
慢性稳定性冠心病（SCAD）是各类冠状动脉疾病（CAD）的统称，包括慢性稳定型心绞痛患者、陈旧性心肌梗死患者以及血运重建术后病情稳定者（即经皮冠状动脉介入治疗、冠状动脉旁路移植术后）。根据2012年美国心脏协会（AHA）/美国心脏病学会（ACC）指南，SCAD的治疗目标是维持或恢复患者的运动耐量、生活质量，并避免心力衰竭等并发症，从而降低死亡率、消除症状并避免不良反应。中医在治疗CAD方面已有2000年的历史，在改善生活质量方面具有优势。运用科学方法评估、论证并总结中医治疗CAD的临床疗效，是中医及中西医结合治疗CAD的一项极其重要的任务。
本研究旨在收集权威中医心内科专家门诊的真实有效病例，建立一个涵盖来自中国32家不同三甲医院2000例患者的中医诊疗信息数据库。主要结局指标包括欧洲五维健康量表（EuroQol-5 Dimensions）和中医四诊，次要结局指标包括心绞痛评分以及一些实验室指标，如心电图、动态心电图、超声心动图和运动平板试验。本研究使用SPSS17.0进行统计分析应用。计数资料采用χ检验，符合正态检验的计量资料采用t检验。对不同疾病、不同证型及不同生活质量影响的用药分析将采用主成分分析、因子分析、聚类分析和点互信息法等。
本研究基于既往证候研究及真实临床有效的慢性SCAD病例，旨在建立一个中医诊疗信息数据库。
