内皮型一氧化氮合酶（-786T>C）基因多态性与偏头痛易感性：一项荟萃分析。
Endothelial nitric oxide synthase (-786T>C) polymorphism and migraine susceptibility: A meta-analysis.
作者信息
Dong Han, Wang Zhi Hao, Dong Bin, Hu Ya Nan, Zhao Hui Ying
机构信息
Department of Geriatric Medicine, The First Hospital of Jilin University, Changchun College of Basic Medical Science, Changchun University of Chinese Medicine, Jilin Province, China.
出版信息
Medicine (Baltimore). 2018 Sep;97(36):e12241. doi: 10.1097/MD.0000000000012241.
BACKGROUND
The aim of this study was to evaluate the correlation between endothelial nitric oxide synthase (eNOS) polymorphism (-786T>C) and migraine susceptibility in a meta-analysis.
METHODS
A literature search was performed for case-control studies from inception to July 30, 2018 focusing on eNOS polymorphism (-786T>C) and risk of migraine. From 454 full-text articles, 6 were included in this study. Heterogeneity was assessed with the I index and quality assessment was performed using the Newcastle-Ottawa scale.
RESULTS
CC genotype was not related to higher susceptibility of migraine compared with TT+ TC genotypes with significant difference (fixed effects model; OR = 1.27; 95% CI = 0.90-1.80; P = .17; I = 18%). However, subgroup analysis showed CC variant increase the risk for migraine compared with TT+ TC genotypes in Caucasian populations (fixed effects model; OR = 1.62; 95% CI = 1.03-2.56; P = .04; I = 18%), which could not be observed in non-Caucasian populations (fixed effects model; OR = 0.88; 95% CI = 0.51-1.53; P = .66; I = 0%). There was no significant difference for other genotypes and alleles between patients with migraine and healthy controls (all P > .05).
CONCLUSION
This meta-analysis indicated that CC variant increases the risk for migraine compared with TT + TC genotypes in Caucasian populations.
背景
本研究旨在通过荟萃分析评估内皮型一氧化氮合酶（eNOS）基因多态性（-786T>C）与偏头痛易感性之间的相关性。
方法
对从研究起始至2018年7月30日的病例对照研究进行文献检索，重点关注eNOS基因多态性（-786T>C）与偏头痛风险。从454篇全文文章中，本研究纳入了6篇。用I指数评估异质性，并使用纽卡斯尔-渥太华量表进行质量评估。
结果
与TT + TC基因型相比，CC基因型与偏头痛的更高易感性无关，差异有统计学意义（固定效应模型；OR = 1.27；95%CI = 0.90 - 1.80；P = 0.17；I = 18%）。然而，亚组分析显示，在白种人群中，与TT + TC基因型相比，CC变异增加了偏头痛风险（固定效应模型；OR = 1.62；95%CI = 1.03 - 2.56；P = 0.04；I = 18%），在非白种人群中未观察到这种情况（固定效应模型；OR = 0.88；95%CI = 0.51 - 1.53；P = 0.66；I = 0%）。偏头痛患者与健康对照之间的其他基因型和等位基因无显著差异（所有P>0.05）。结论：这项荟萃分析表明，在白种人群中，与TT + TC基因型相比，CC变异增加了偏头痛风险。
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