Unit of Nutritional Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, SE-171 77 Stockholm, Sweden.
Stroke Research Group, Department of Clinical Neurosciences, University of Cambridge, Cambridge 01223, UK.
Nutrients. 2018 Sep 6;10(9):1243. doi: 10.3390/nu10091243.
We conducted Mendelian randomization analyses to investigate the associations of serum parathyroid hormone (S-PTH) and serum 25-hydroxyvitamin D (S-25OHD) concentrations with Alzheimer's disease (AD). Five and seven single nucleotide polymorphisms associated with S-PTH and S-25OHD concentrations, respectively, were used as instrumental variables. Data for AD were acquired from the International Genomics of Alzheimer's Project (17,008 AD cases and 37,154 controls). Genetically higher S-PTH concentrations were not associated with AD (odds ratio per standard deviation increase in S-PTH = 1.11; 95% CI 0.97⁻1.26; = 0.12). In contrast, all seven 25OHD-increasing alleles were inversely associated with AD and two of the associations were statistically significant ( < 0.05). The odds ratio of AD per genetically-predicted one standard deviation increase in S-25OHD was 0.86 (95% CI 0.78⁻0.94; = 0.002). This study provides evidence that vitamin D may play a role in AD but found no significant association between S-PTH and AD.
我们进行了孟德尔随机化分析，以研究血清甲状旁腺激素（S-PTH）和血清 25-羟维生素 D（S-25OHD）浓度与阿尔茨海默病（AD）之间的关联。分别使用与 S-PTH 和 S-25OHD 浓度相关的 5 个和 7 个单核苷酸多态性作为工具变量。AD 的数据来自国际阿尔茨海默病基因组学项目（17008 例 AD 病例和 37154 例对照）。S-PTH 浓度每增加一个标准差，AD 的发病风险并没有显著增加（S-PTH 每增加一个标准差的比值比 = 1.11；95%CI 0.97⁻1.26； = 0.12）。相反，所有七个增加 25OHD 的等位基因与 AD 呈负相关，其中两个关联具有统计学意义（ < 0.05）。S-25OHD 每增加一个遗传预测标准差，AD 的比值比为 0.86（95%CI 0.78⁻0.94； = 0.002）。本研究提供了维生素 D 可能在 AD 中发挥作用的证据，但未发现 S-PTH 与 AD 之间存在显著关联。
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