Nagamine Takahiko
Department of Psychiatric Internal Medicine, Sunlight Brain Research Center, Hofu 7470066, Yamaguchi, Japan.
World J Methodol. 2025 Dec 20;15(4):104664. doi: 10.5662/wjm.v15.i4.104664.
Nutritional psychiatry is a rapidly expanding field of research, with mounting evidence suggesting that nutritional factors may play a role in the development of psychiatric disorders.
To examine the level of evidence for nutritional psychiatry.
A scoping review was conducted to assess the current state of nutritional psychiatry, including a search for randomized controlled trials (RCTs).
The review identified a total of seven papers, with many concentrating on the relationship between depression and the gut microbiome. A salient issue that emerged from this review was the paucity of sample size in many studies. The inherent complexity of nutritional studies, characterized by a multitude of potential factors and exposures that often act as confounders, poses significant challenges to the development of effective RCT designs. The analysis revealed that probiotics, though demonstrating efficacy, exhibited a modest effect size.
Conducting RCTs with effective markers is imperative from these studies. The implementation of Mendelian randomization and the investigation of mechanisms in basic research are essential complementary approaches.
营养精神病学是一个迅速发展的研究领域，越来越多的证据表明营养因素可能在精神疾病的发生发展中起作用。
研究营养精神病学的证据水平。
进行了一项范围综述，以评估营养精神病学的现状，包括检索随机对照试验（RCT）。
该综述共纳入7篇论文，许多论文聚焦于抑郁症与肠道微生物群之间的关系。本次综述中出现的一个突出问题是许多研究的样本量不足。营养研究固有的复杂性，其特点是众多潜在因素和暴露因素常常充当混杂因素，这给有效RCT设计的开展带来了重大挑战。分析表明，益生菌虽然显示出疗效，但其效应量较小。
从这些研究来看，开展具有有效标志物的RCT至关重要。孟德尔随机化的实施以及基础研究中的机制探究是必不可少的补充方法。
