a Applied Vision Research Group, Faculty of Optics and Optometry , Universidad Complutense de Madrid , Madrid , Spain.
Curr Eye Res. 2019 Jan;44(1):82-88. doi: 10.1080/02713683.2018.1522648. Epub 2018 Sep 27.
Purpose/Aim: Impaired mesopic visual acuity (VA) is a risk factor for incident early age-related macular degeneration (AMD) This study examines relationships between macular thickness measurements and photopic or mesopic VA in healthy eyes.
In 38 young and 39 older healthy individuals, total, inner, and outer retinal layer (IRL and ORL) thicknesses were measured in the macula region through spectral-domain optical coherence tomography (SD-OCT). Measurements were made across three subfields centered at the fovea: central foveal, pericentral, and peripheral. Best-corrected distance high-contrast (HC) and low-contrast (LC) VA were measured using Bailey-Lovie logMAR letter charts under photopic and mesopic luminance conditions. In addition, the low luminance deficit in VA (LLD, difference between photopic and mesopic VA) was calculated. Relationships were examined through Spearman correlation in each age group and through multiple linear regressions across all eyes.
No significant correlations were detected between photopic VA (HC-VA and LC-VA) and macular thickness measurements in each age group. In mesopic conditions, age and pupil size were independent predictors of HC-VA (p = 0.001) and age and pericentral ORL thickness predictors of LC-VA (p = 0.001). Central foveal thickness emerged as the unique independent predictor of LLD (HC-VA, p = 0.013 and LC-VA, p = 0.005). Only in the older age group, was central foveal thicknesses correlated with LLD (HC-VA, r = + 0.45; p = 0.004 and LC-VA, r = + 0.33, p = 0.038).
Greater macular thicknesses were related to worse mesopic VA and low luminance deficit in healthy subjects.
目的/目的：中值视觉敏度（VA）受损是早期年龄相关性黄斑变性（AMD）的一个风险因素。本研究探讨了健康眼中黄斑厚度测量值与明视和中值 VA 之间的关系。
在 38 名年轻和 39 名老年健康个体中，通过谱域光相干断层扫描（SD-OCT）测量黄斑区的总、内和外视网膜层（IRL 和 ORL）厚度。在三个以黄斑为中心的子区域进行测量：中央黄斑、近中央和周边。使用 Bailey-Lovie 对数 MAR 字母图表在明视和中值亮度条件下测量最佳矫正距离高对比度（HC）和低对比度（LC）VA。此外，还计算了 VA 的低亮度缺陷（LLD，明视和中值 VA 之间的差异）。在每个年龄组中通过 Spearman 相关进行关系检查，并在所有眼睛中通过多元线性回归进行检查。
在每个年龄组中，明视 VA（HC-VA 和 LC-VA）与黄斑厚度测量值之间均未检测到显著相关性。在中值条件下，年龄和瞳孔大小是 HC-VA 的独立预测因子（p=0.001），年龄和近中央 ORL 厚度是 LC-VA 的独立预测因子（p=0.001）。中央黄斑厚度是 LLD 的唯一独立预测因子（HC-VA，p=0.013 和 LC-VA，p=0.005）。只有在老年组中，中央黄斑厚度与 LLD 相关（HC-VA，r=+0.45；p=0.004 和 LC-VA，r=+0.33，p=0.038）。
在健康受试者中，更大的黄斑厚度与更差的中值 VA 和低亮度缺陷相关。
