Applied Vision Research Group, Faculty of Optics and Optometry, Universidad Complutense de Madrid, Madrid, Spain.
Invest Ophthalmol Vis Sci. 2018 Nov 1;59(13):5487-5493. doi: 10.1167/iovs.18-25334.
To examine relationships between the thicknesses of ganglion cell (GC)-related macular layers and central photopic or mesopic contrast sensitivity (CS) in healthy eyes.
Measurements were made in 38 young and 38 older healthy individuals. Total, inner, and outer retinal layer (IRL) thicknesses were measured in the macula region through spectral-domain optical coherence tomography (SD-OCT) across three subfields, or rings, centered at the fovea: central foveal, pericentral, and peripheral. Ganglion cell complex and circumpapillary retinal nerve fiber layer thicknesses were also measured. Low-spatial-frequency CS for gratings presented at the central 10° visual field were measured through computerized psychophysical tests under photopic and mesopic conditions. Relationships were examined by uni- and multivariate regression analysis.
Peripheral IRL thickness emerged as the only independent predictor of photopic CS (P = 0.001) in the young group and of photopic (P = 0.026) and mesopic CS (P = 0.001) in the older group. The slopes of regression lines used to predict CS from peripheral IRL thickness were significantly different for pair-wise comparisons of both photopic CS and age group (P = 0.0001) and mesopic CS (P = 0.0001) and age group. These models explained 37% of the variability in photopic CS and 36% of the variability in mesopic CS.
Macular IRL thinning likely due to GC loss was related to reduced photopic and mesopic CS in older healthy eyes. In contrast, in the young eyes, a thicker macular IRL, possibly indicating transient gliosis, was associated with reduced CS.
研究健康眼中神经节细胞（GC）相关的黄斑层厚度与中央明视或中视对比敏感度（CS）之间的关系。
对 38 名年轻和 38 名老年健康个体进行了测量。通过光谱域光学相干断层扫描（SD-OCT）在黄斑区域的三个亚区或环中测量总、内和外视网膜层（IRL）厚度，这些亚区或环以黄斑中心为中心：中央黄斑、近黄斑和周边。还测量了神经节细胞复合体和环周视网膜神经纤维层的厚度。通过计算机心理物理测试在明视和中视条件下测量在中央 10°视野呈现的光栅的低空间频率 CS。通过单变量和多变量回归分析检查关系。
在年轻组中，周边 IRL 厚度是明视 CS（P = 0.001）的唯一独立预测因子，在老年组中，周边 IRL 厚度是明视（P = 0.026）和中视 CS（P = 0.001）的唯一独立预测因子。用于从周边 IRL 厚度预测 CS 的回归线斜率在明视 CS（P = 0.0001）和年龄组（P = 0.0001）以及中视 CS（P = 0.0001）和年龄组的两两比较中差异显著。这些模型解释了明视 CS 变异性的 37%和中视 CS 变异性的 36%。
黄斑 IRL 变薄可能是由于 GC 丢失，与老年健康眼中的明视和中视 CS 降低有关。相比之下，在年轻眼中，更厚的黄斑 IRL 可能表明短暂的神经胶质增生，与 CS 降低有关。
