Hirano Naoko, Sakamoto Kazuichi
a Graduate School of Life and Environmental Sciences , University of Tsukuba , Tsukuba , Ibaraki , Japan.
Biosci Biotechnol Biochem. 2018 Sep 10:1-7. doi: 10.1080/09168451.2018.1518699.
Aromatherapy uses plant essential oils and fragrant ingredients for relaxation, sleep assistance, and improvement of restlessness related to dementia. Certain aromatic substances increase the life span and stress tolerance of nematodes. We investigated effects of exposure to linalool, a linear chain monoterpenic alcohol that is present in the essential oils of many plants, and its optical isomer, l-linalool, in Caenorhabditis elegans. Nematodes were repelled by the odor of both linalool and l-linalool; however, linalool odor stimulation decreased fat accumulation and increased motility after thermal stress. Analysis of a gene-deficient mutant revealed that the DAF-16 insulin-signaling pathway, which is involved in heat stress tolerance, was enhanced by linalool treatment. Linalool stimulation increased the expression of downstream genes such as sod-3 and hsp-12.6 via DAF-16. We conclude that linalool odor induces a repelling behavior in nematodes, improves heat stress tolerance through the DAF-16 signaling pathway, and affects fat accumulation.
芳香疗法使用植物精油和芳香成分来促进放松、辅助睡眠，并改善与痴呆症相关的烦躁不安。某些芳香物质可延长线虫的寿命并提高其应激耐受性。我们研究了暴露于芳樟醇（一种存在于许多植物精油中的直链单萜醇）及其旋光异构体L-芳樟醇对秀丽隐杆线虫的影响。线虫会被芳樟醇和L-芳樟醇的气味驱避；然而，芳樟醇气味刺激可减少脂肪积累，并增加热应激后的运动能力。对基因缺陷突变体的分析表明，参与热应激耐受性的DAF-16胰岛素信号通路通过芳樟醇处理得到增强。芳樟醇刺激通过DAF-16增加了下游基因如sod-3和hsp-12.6的表达。我们得出结论，芳樟醇气味在秀丽隐杆线虫中诱导排斥行为，通过DAF-16信号通路提高热应激耐受性，并影响脂肪积累。
