RNA Group, Department of Biochemistry, University of Sherbrooke, Sherbrooke, Quebec J1H 5N4, Canada; email:
Annu Rev Microbiol. 2018 Sep 8;72:141-161. doi: 10.1146/annurev-micro-090817-062607.
The first report of trans-acting RNA-based regulation in bacterial cells dates back to 1984. Subsequent studies in diverse bacteria unraveled shared properties of trans-acting small regulatory RNAs, forming a clear definition of these molecules. These shared characteristics have been used extensively to identify new small RNAs (sRNAs) and their interactomes. Recently however, emerging technologies able to resolve RNA-RNA interactions have identified new types of regulatory RNAs. In this review, we present a broader definition of trans-acting sRNA regulators and discuss their newly discovered intrinsic characteristics.
第一篇关于细菌细胞中转录 RNA 调控的报告可以追溯到 1984 年。随后在不同细菌中的研究揭示了转录调控小 RNA 的共同特性，从而对这些分子进行了明确的定义。这些共同特性已被广泛用于鉴定新的小 RNA(sRNA)及其相互作用组。然而，最近出现的能够解析 RNA-RNA 相互作用的新技术已经鉴定出了新的调控 RNA 类型。在这篇综述中，我们提出了一个更广泛的转录调控 sRNA 调控因子定义，并讨论了它们新发现的内在特性。
