Laboratory of Sensory Processing, Brain Mind Institute, Faculty of Life Sciences, École Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland.
Laboratory of Sensory Processing, Brain Mind Institute, Faculty of Life Sciences, École Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland; Department of Biological Sciences, KAIST, Daejeon, Republic of Korea.
Trends Neurosci. 2019 Jan;42(1):66-77. doi: 10.1016/j.tins.2018.08.011. Epub 2018 Sep 7.
Precisely wired neuronal circuits process sensory information in a learning- and context-dependent manner in order to govern behavior. Simple sensory decision-making tasks in rodents are now beginning to reveal the contributions of distinct cell types and brain regions participating in the conversion of sensory information into learned goal-directed motor output. Task learning is accompanied by target-specific routing of sensory information to specific downstream cortical regions, with higher-order cortical regions such as the posterior parietal cortex, medial prefrontal cortex, and hippocampus appearing to play important roles in learning- and context-dependent processing of sensory input. An important challenge for future research is to connect cell-type-specific activity in these brain regions with motor neurons responsible for action initiation.
精确布线的神经元回路以学习和上下文依赖的方式处理感觉信息，以控制行为。啮齿动物的简单感觉决策任务现在开始揭示参与将感觉信息转换为学习的目标导向运动输出的不同细胞类型和脑区的贡献。任务学习伴随着感觉信息到特定下游皮质区域的特定目标特定路由，后顶叶皮层、内侧前额叶皮层和海马等高级皮质区域似乎在学习和上下文依赖的感觉输入处理中发挥重要作用。未来研究的一个重要挑战是将这些脑区中的细胞类型特异性活动与负责动作启动的运动神经元联系起来。
