无症状同性恋男性中巨细胞病毒在精液中的排泄与HTLV-III血清阳性相关。

Excretion of cytomegalovirus in semen associated with HTLV-III seropositivity in asymptomatic homosexual men.

作者信息

Rinaldo C R, Kingsley L A, Lyter D W, Bodner A J, Weiss S H, Saxinger W C

出版信息

J Med Virol. 1986 Sep;20(1):17-22. doi: 10.1002/jmv.1890200104.

DOI:10.1002/jmv.1890200104

PMID:3020166

Abstract

We studied 56 asymptomatic homosexual male volunteers in Pittsburgh for 1 1/2 yr for relationships between cytomegalovirus (CMV) and human T-lymphotropic virus type III (HTLV-III) infections. CMV was most frequently isolated from semen (8%) as compared with throat washings (5.9%) and urine (0%) on initial testing of CMV-seropositive subjects. Other viruses commonly isolated from immunosuppressed patients (herpes simplex virus, adenovirus) were rarely detected in this cohort. Seropositivity to HTLV-III was significantly associated with isolation of CMV from semen in our asymptomatic cohort (odds ratio = 9.5, p = .008). These results suggest that HTLV-III infection is associated with selective, temporal activation of CMV in the genital tract of asymptomatic homosexual men.

摘要

我们在匹兹堡对56名无症状同性恋男性志愿者进行了为期1年半的研究，以探讨巨细胞病毒（CMV）感染与人类嗜T淋巴细胞病毒III型（HTLV-III）感染之间的关系。在对CMV血清反应阳性的受试者进行初次检测时，CMV最常从精液中分离出来（8%），相比之下，从咽洗液中分离出来的比例为5.9%，从尿液中未分离出（0%）。在该队列中，其他通常从免疫抑制患者中分离出的病毒（单纯疱疹病毒、腺病毒）很少被检测到。在我们的无症状队列中，HTLV-III血清反应阳性与从精液中分离出CMV显著相关（优势比=9.5，p=0.008）。这些结果表明，HTLV-III感染与无症状同性恋男性生殖道中CMV的选择性、暂时性激活有关。