治疗性生活方式改变通过抑制代谢综合征患者髓过氧化物酶介导的氧化改善高密度脂蛋白功能。
Therapeutic Lifestyle Changes Improve HDL Function by Inhibiting Myeloperoxidase-Mediated Oxidation in Patients With Metabolic Syndrome.
机构信息
Division of Nephrology, Department of Internal Medicine, University of Michigan, Ann Arbor, MI.
Peking University Health Sciences Center, Beijing, China.
出版信息
Diabetes Care. 2018 Nov;41(11):2431-2437. doi: 10.2337/dc18-0049. Epub 2018 Sep 10.
OBJECTIVE
Phagocyte-derived myeloperoxidase (MPO) and proinflammatory HDL are associated with metabolic syndrome (MetS) and increased cardiovascular disease risk. Therapeutic lifestyle changes (TLCs), such as a Mediterranean diet and exercise, decrease this risk. However, the link among TLCs, HDL, and MPO-mediated oxidative stress remains unclear.
RESEARCH DESIGN AND METHODS
In this study, we characterized changes in cholesterol efflux capacity (CEC), a metric of HDL function; MPO-mediated oxidation; and the HDL proteomic profile in 25 patients with MetS who underwent 12 weeks of TLCs.
RESULTS
After 12 weeks, before significant changes to HDL levels, most MetS components improved as a result of the TLCs. CEC was significantly increased, and HDL MPO oxidation products, 3-chlorotyrosine and 3-nitrotyrosine, were decreased with TLCs. The changes in CEC were inversely related to the unit changes in 3-chlorotyrosine after we controlled for changes in the other MetS components. TLCs did not remodel the HDL proteome.
CONCLUSIONS
In summary, TLCs improved HDL function by inhibiting MPO-mediated oxidative stress even before appreciable changes in HDL levels.
目的
吞噬细胞衍生的髓过氧化物酶（MPO）和促炎型高密度脂蛋白（HDL）与代谢综合征（MetS）及心血管疾病风险增加有关。治疗性生活方式改变（TLCs），如地中海饮食和运动，可以降低这种风险。然而，TLCs、HDL 和 MPO 介导的氧化应激之间的联系仍不清楚。
研究设计和方法
在这项研究中，我们对 25 名接受 12 周 TLCs 的 MetS 患者的胆固醇外排能力（CEC）、MPO 介导的氧化和 HDL 蛋白质组谱的变化进行了特征描述。
结果
在 12 周后，在 HDL 水平没有明显变化之前，由于 TLCs，大多数 MetS 成分得到了改善。CEC 显著增加，HDL MPO 氧化产物 3-氯酪氨酸和 3-硝基酪氨酸减少。在控制其他 MetS 成分的变化后，CEC 的变化与 3-氯酪氨酸的单位变化呈负相关。TLCs 没有重塑 HDL 蛋白质组。
结论
总之，TLCs 通过抑制 MPO 介导的氧化应激改善了 HDL 功能，即使在 HDL 水平没有明显变化之前也是如此。
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