钴催化简单烯烃的烯丙基C(sp) -H键与酮的亲核加成反应。
Cobalt-catalyzed nucleophilic addition of the allylic C(sp)-H bond of simple alkenes to ketones.
作者信息
Mita Tsuyoshi, Uchiyama Masashi, Michigami Kenichi, Sato Yoshihiro
机构信息
Faculty of Pharmaceutical Sciences, Hokkaido University, Sapporo 060-0812, Japan.
出版信息
Beilstein J Org Chem. 2018 Aug 2;14:2012-2017. doi: 10.3762/bjoc.14.176. eCollection 2018.
Abstract
We herein describe a cobalt/Xantphos-catalyzed regioselective addition of simple alkenes to acetophenone derivatives, affording branched homoallylic alcohols in high yields with perfect branch selectivities. The intermediate of the reaction would be a nucleophilic allylcobalt(I) species generated via cleavage of the low reactive allylic C(sp)-H bond of simple terminal alkenes.
摘要
我们在此描述了一种钴/双(二苯基膦基)甲烷催化的简单烯烃对苯乙酮衍生物的区域选择性加成反应，该反应能以高收率和完美的支链选择性得到支链型高烯丙醇。该反应的中间体可能是通过简单末端烯烃中低活性烯丙基C(sp)-H键的裂解生成的亲核烯丙基钴(I)物种。
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