Feitz W F, Debruyne F M, Vooijs G P, Herman C J, Ramaekers F C
J Urol. 1986 Oct;136(4):922-31. doi: 10.1016/s0022-5347(17)45133-0.
Immunocytochemical techniques have become valuable tools in many fields of clinical pathology and medical research. Especially the development of highly specific (monoclonal) antibodies to a large variety of tissue antigens has in recent years led to the establishment of sensitive tissue markers. One of the most promising types of tissue specific markers so far is represented by the intermediate filament proteins. Since the findings of this rapidly expanding field are also being applied in urology, we have reviewed the current data in order to describe the new insights in tumor biology and histogenesis, as well as their application in diagnostic pathology.
免疫细胞化学技术已成为临床病理学和医学研究众多领域中的重要工具。特别是近年来针对多种组织抗原开发出高特异性（单克隆）抗体，从而建立了灵敏的组织标志物。迄今为止，最有前景的一类组织特异性标志物以中间丝蛋白为代表。鉴于这一快速发展领域的研究成果也正应用于泌尿外科，我们回顾了当前数据，以阐述肿瘤生物学和组织发生学方面的新见解及其在诊断病理学中的应用。
