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Disseminated cutaneous leishmaniasis: ulcerovegetative and ulcero-crusted lesions.播散性皮肤利什曼病：溃疡性增殖性和溃疡结痂性损害。
Braz J Infect Dis. 2017 Mar-Apr;21(2):201-202. doi: 10.1016/j.bjid.2016.10.014. Epub 2016 Dec 21.
2
Cutaneous leishmaniasis: immune responses in protection and pathogenesis.皮肤利什曼病：保护和发病机制中的免疫反应。
Nat Rev Immunol. 2016 Sep;16(9):581-92. doi: 10.1038/nri.2016.72. Epub 2016 Jul 18.
3
Diffuse and disseminated cutaneous leishmaniasis: clinical cases experienced in Ecuador and a brief review.弥漫性和播散性皮肤利什曼病：厄瓜多尔的临床病例及简要综述
Trop Med Health. 2016 Mar 14;44:2. doi: 10.1186/s41182-016-0002-0. eCollection 2016.
4
AMERICAN CUTANEOUS LEISHMANIASIS WITH UNUSUAL CLINICAL PRESENTATION AND RESPONSE TO TREATMENT.具有不寻常临床表现及治疗反应的美洲皮肤利什曼病
Rev Inst Med Trop Sao Paulo. 2016;58:20. doi: 10.1590/S1678-9946201658020. Epub 2016 Mar 22.
5
Identification and Biological Characterization of Leishmania (Viannia) guyanensis Isolated from a Patient with Tegumentary Leishmaniasis in Goiás, a Nonendemic Area for This Species in Brazil.从巴西戈亚斯州一名皮肤利什曼病患者中分离出的圭亚那利什曼原虫（维安亚利什曼原虫）的鉴定及生物学特性研究。该地区并非该物种在巴西的流行区域。
Biomed Res Int. 2015;2015:350764. doi: 10.1155/2015/350764. Epub 2015 Oct 25.
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A randomized clinical trial comparing meglumine antimoniate, pentamidine and amphotericin B for the treatment of cutaneous leishmaniasis by Leishmania guyanensis.一项比较葡甲胺锑酸盐、喷他脒和两性霉素B治疗圭亚那利什曼原虫引起的皮肤利什曼病的随机临床试验。
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Randomized controlled clinical trial to access efficacy and safety of miltefosine in the treatment of cutaneous leishmaniasis Caused by Leishmania (Viannia) guyanensis in Manaus, Brazil.随机对照临床试验评估米替福新治疗巴西玛瑙斯地区由圭亚那利什曼原虫引起的皮肤利什曼病的疗效和安全性。
Am J Trop Med Hyg. 2011 Feb;84(2):255-60. doi: 10.4269/ajtmh.2011.10-0155.
8
Atypical manifestations of tegumentary leishmaniasis in a transmission area of Leishmania braziliensis in the state of Bahia, Brazil.巴西巴伊亚州巴西利什曼原虫传播地区皮肤利什曼病的非典型表现
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9
Leishmania (Viannia) guyanensis induces low immunologic responsiveness in leishmaniasis patients from an endemic area of the Brazilian Amazon Highland.圭亚那利什曼原虫（维安亚利什曼原虫）可使巴西亚马逊高地流行区的利什曼病患者免疫反应性降低。
Am J Trop Med Hyg. 2009 Mar;80(3):339-44.
10
Reviewing the role of the dendritic Langerhans cells in the immunopathogenesis of American cutaneous leishmaniasis.综述树突状朗格汉斯细胞在美国皮肤利什曼病免疫发病机制中的作用。
Trans R Soc Trop Med Hyg. 2008 Nov;102(11):1075-80. doi: 10.1016/j.trstmh.2008.05.020. Epub 2008 Jul 3.

病例报告：混合感染患者中的非典型皮肤利什曼病。

Case Report: Atypical Cutaneous Leishmaniasis in a Patient with Mixed and Infection.

机构信息

Department of Microbiology, Immunology and Parasitology, Faculty President Antônio Carlos-Porto Nacional, Tocantins, Brazil.

Faculty President Antônio Carlos-Porto Nacional, Tocantins, Brazil.

出版信息

Am J Trop Med Hyg. 2018 Nov;99(5):1165-1169. doi: 10.4269/ajtmh.17-0760.

DOI:10.4269/ajtmh.17-0760
PMID:30203744
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6221246/
Abstract

The disseminated form of leishmaniasis is a serious and rare disease, being diagnosed in 2% of the cutaneous cases registered per year in Brazil. The main characteristic is the appearance of multiple pleomorphic lesions on the cutaneous surface. A 68-year-old male from the rural area of Tocantins, Brazil, presented atypical disseminated cutaneous leishmaniasis (ACL). The clinical course and histopathological and immunological findings presented a mixed pattern that hindered diagnosis and therapeutic management. Molecular typing revealed a mixed infection with and . Molecular identification of the agents responsible for ACL is important for adequate therapeutic planning, minimizing the possibility of sequellae that impact the quality of life of the patient.

摘要

皮肤利什曼病的播散型是一种严重且罕见的疾病，在巴西每年登记的皮肤病例中，发病率占 2%。其主要特征是皮肤表面出现多个多形性病变。巴西托坎廷斯农村地区的一名 68 岁男性患者出现了非典型性皮肤播散性利什曼病（ACL）。临床表现、组织病理学和免疫学检查结果呈混合模式，这对诊断和治疗管理造成了阻碍。分子分型显示合并了 和 感染。ACL 致病因子的分子鉴定对于合理的治疗计划非常重要，可以最大程度地减少对患者生活质量产生影响的后遗症的发生。