遗传因素对口颌关节紊乱病的多方面影响：最新综述。
The many faces of genetic contributions to temporomandibular joint disorder: An updated review.
机构信息
Department of Oral and Maxillofacial Surgery, Universidade Positivo, Curitiba, Brazil.
Department of Oral and Maxillofacial Surgery, Universidade Federal do Paraná, Curitiba, Brazil.
出版信息
Orthod Craniofac Res. 2018 Nov;21(4):186-201. doi: 10.1111/ocr.12239. Epub 2018 Sep 11.
OBJECTIVES
The aim was to review the literature regarding genetic contributions to temporomandibular joint disorder (TMD) after our 2008 publication.
SETTING AND SAMPLE POPULATION
Literature review.
MATERIAL AND METHODS
PubMed and MEDLINE were used to obtain literature in any language regarding genes and TMD, using the keywords "temporomandibular joint disorder" and "temporomandibular joint dysfunction" for studies published from 2009 to 2017.
RESULTS
In our search, 274 studies were found. We excluded 76 studies from animal models, 22 studies that were in vitro and 120 reports that were not cohort or case-control studies. Of the 274 results, 56 articles were selected for this review. Genes that are suggested to contribute to TMD included the ones related to disc and bone alterations as well as pain sensation.
CONCLUSION
Currently, no evidence of associated genetic variants, which can determine the development of TMD in individuals, could be translated to novel clinical management and public health strategies for patients suffering from TMD.
目的
回顾我们 2008 年发表论文之后，有关颞下颌关节紊乱（TMD）的遗传贡献的文献。
设置和样本人群
文献回顾。
材料和方法
使用 PubMed 和 MEDLINE，检索 2009 年至 2017 年发表的任何语种有关基因与 TMD 的文献，关键词为“temporomandibular joint disorder”和“temporomandibular joint dysfunction”。
结果
检索发现 274 项研究，排除了 76 项动物模型研究、22 项体外研究和 120 项非队列或病例对照研究。在 274 项研究结果中，有 56 篇文章被选入本次综述。被认为与 TMD 相关的基因包括与关节盘和骨改变以及疼痛感觉相关的基因。
结论
目前，尚无证据表明与 TMD 个体发病相关的遗传变异可转化为 TMD 患者的新临床管理和公共卫生策略。
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