a Department of Psychiatry & Mental Health , University of Cape Town , Cape Town , South Africa.
World J Biol Psychiatry. 2018;19(sup1):S46-S52. doi: 10.1080/15622975.2018.1492736.
Adjustment disorder has been reconceptualized as a trauma- and stressor-related condition, and there is a growing understanding of the psychobiology of stress responses. Against this context it is timely to review of the pharmacotherapy of adjustment disorder.
A comprehensive electronic database (Pubmed) was searched for randomised controlled trials of the pharmacotherapy of adjustment disorder. Data from each trial were extracted and collated.
To date there have been relatively few controlled trials in this area. Comparator trials provide limited support for a number of antidepressant agents, and a series of studies indicate that etifoxine is superior to buspirone and benzodiazepines for adjustment disorder with anxiety.
The work done has been useful insofar as it provides clinicians with some insights into the advantages and disadvantages of a number of pharmacotherapy options. Additional rigorously designed trials are needed to further advance the field.
适应障碍已被重新概念化为与创伤和应激源相关的疾病，并且人们对应激反应的心理生物学有了越来越深入的了解。在此背景下，及时审查适应障碍的药物治疗是很有必要的。
对药物治疗适应障碍的随机对照试验进行了全面的电子数据库（Pubmed）检索。从每个试验中提取和整理数据。
迄今为止，该领域的对照试验相对较少。对照试验为许多抗抑郁药提供了有限的支持，一系列研究表明，对于焦虑型适应障碍，依托菲林优于丁螺环酮和苯二氮䓬类药物。
所做的工作是有用的，因为它为临床医生提供了一些关于许多药物治疗选择的优缺点的见解。需要进行更多严格设计的试验来进一步推动该领域的发展。
