Fekete M, van Ree J M, Niesink R J, de Wied D
Physiol Behav. 1985 Jun;34(6):883-7. doi: 10.1016/0031-9384(85)90008-3.
Disrupting circadian organization in rats by phase-shifting the illumination cycle or by exposure to a reversed day/night cycle or to continuous light, resulted in retrograde amnesia for passive avoidance behavior. This retrograde amnesia induced by phase-shifting lasted at least 2 days, and gradually diminished the longer the rats were exposed to the new illumination cycle. Retention performance was not impaired when rats were exposed to phase-shifting for 3-5 days before the learning trial. The retrograde amnesia due to changing the illumination cycle is probably due to retrieval disturbances. Extinction of active avoidance behavior was facilitated in rats exposed to a phase-shifted illumination cycle, but social and explorative behavior of rats tested in dyadic encounters were not affected by changing the normal illumination cycle. It is concluded that phase-shifting may result in amnesia for newly learned behavioral responses, but not for more innate behavioral patterns.
通过改变光照周期的相位、暴露于颠倒的昼夜周期或持续光照来扰乱大鼠的昼夜节律，会导致被动回避行为出现逆行性遗忘。这种由相位改变引起的逆行性遗忘至少持续2天，并且大鼠暴露于新光照周期的时间越长，遗忘逐渐减轻。在学习试验前让大鼠暴露于相位改变3 - 5天，其记忆保持能力并未受损。因改变光照周期导致的逆行性遗忘可能是由于提取障碍。暴露于相位改变的光照周期的大鼠，主动回避行为的消退得到促进，但在二元互动测试中大鼠的社交和探索行为不受正常光照周期改变的影响。得出的结论是，相位改变可能导致对新习得的行为反应出现遗忘，但对更具先天性的行为模式则不会。
