从. 的根木中分离得到的新型抗炎阿朴啡和木脂素衍生物。

New Anti-Inflammatory Aporphine and Lignan Derivatives from the Root Wood of .

机构信息

Department of General Surgery, Taitung MacKay Memorial Hospital, Taitung City 950, Taiwan.

Department of Medicine, Mackay Medical College, New Taipei City 252, Taiwan.

出版信息

Molecules. 2018 Sep 7;23(9):2286. doi: 10.3390/molecules23092286.

DOI:10.3390/molecules23092286

PMID:30205430

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6225223/

Abstract

A new aporphine, 3-hydroxyhernandonine () and a new lignin, 4'--demethyl-7--methyldehydropodophyllotoxin (), have been isolated from the root wood of , together with thirteen known compounds (⁻). The structures of these compounds were determined through mass spectrometry (MS) and spectroscopic analyses. The known isolate, 2--methyl-7-oxolaetine (), was first isolated from natural sources. Among the isolated compounds, 3-hydroxyhernandonine (), 4'--demethyl-7--methyldehydropodophyllotoxin (), hernandonine (), oxohernangerine (), and oxohernagine () displayed inhibition (IC values ≤5.72 μg/mL) of superoxide anion production by human neutrophils in response to formyl-l-methionyl-l-leucyl-l-phenylalanine/cytochalasin B (fMLP/CB). In addition, 3-hydroxyhernandonine (), 4'--demethyl-7--methyldehydropodophyllotoxin (), oxohernangerine (), and oxohernagine () suppressed fMLP/CB-induced elastase release with IC values ≤5.40 μg/mL.

摘要

从瑞香科植物华瑞香的根木部分离得到了一个新的阿朴啡型生物碱 3-羟基汉防己碱 () 和一个新的木脂素 4'--去甲-7--甲基去氢鬼臼毒素 ()，此外还分离得到了 13 个已知化合物 (⁻)。通过质谱 (MS) 和光谱分析确定了这些化合物的结构。已知的分离物 2--甲基-7-氧代吖啶 () 是首次从天然来源中分离得到的。在所分离的化合物中，3-羟基汉防己碱 ()、4'--去甲-7--甲基去氢鬼臼毒素 ()、汉防己甲素 ()、氧化汉防己碱 () 和氧化汉防己宁 () 对人中性粒细胞在甲酰基-l-甲硫氨酸-l-亮氨酸-l-苯丙氨酸/细胞松弛素 B (fMLP/CB) 刺激下产生的超氧阴离子具有抑制作用 (IC 值 ≤5.72 μg/mL)。此外，3-羟基汉防己碱 ()、4'--去甲-7--甲基去氢鬼臼毒素 ()、氧化汉防己碱 () 和氧化汉防己宁 () 可抑制 fMLP/CB 诱导的弹性蛋白酶释放，IC 值 ≤5.40 μg/mL。