Department of Regenerative and Cancer Cell Biology, Albany Medical College, 47 New Scotland Avenue, Albany, NY, 12208, USA.
Indiana University, 975 W. Walnut Street, Indianapolis, IN, 46202, USA.
Cell Mol Life Sci. 2018 Nov;75(22):4177-4185. doi: 10.1007/s00018-018-2913-x. Epub 2018 Sep 11.
Integrins engage components of the extracellular matrix, and in collaboration with other receptors, regulate signaling cascades that impact cell behavior in part by modulating the cell's cytoskeleton. Integrins have long been known to function together with the actin cytoskeleton to promote cell adhesion, migration, and invasion, and with the intermediate filament cytoskeleton to mediate the strong adhesion needed for the maintenance and integrity of epithelial tissues. Recent studies have shed light on the crosstalk between integrin and the microtubule cytoskeleton. Integrins promote microtubule nucleation, growth, and stabilization at the cell cortex, whereas microtubules regulate integrin activity and remodeling of adhesion sites. Integrin-dependent stabilization of microtubules at the cell cortex is critical to the establishment of apical-basal polarity required for the formation of epithelial tissues. During cell migration, integrin-dependent microtubule stabilization contributes to front-rear polarity, whereas microtubules promote the turnover of integrin-mediated adhesions. This review focuses on this interdependent relationship and its impact on cell behavior and function.
整合素与细胞外基质的成分结合，并与其他受体协同作用，调节信号级联反应，部分通过调节细胞骨架来影响细胞行为。长期以来，整合素一直被认为与肌动蛋白细胞骨架一起促进细胞黏附、迁移和侵袭，并与中间丝细胞骨架一起介导维持和完整的上皮组织所需的强黏附。最近的研究揭示了整合素与微管细胞骨架之间的串扰。整合素促进细胞皮层处微管的核形成、生长和稳定，而微管调节整合素活性和黏附位点的重塑。细胞皮层处整合素依赖性微管的稳定对于上皮组织形成所需的顶端-基底极性的建立至关重要。在细胞迁移过程中，整合素依赖性微管稳定有助于前后极性，而微管促进整合素介导的黏附的周转。本综述重点介绍这种相互依存的关系及其对细胞行为和功能的影响。
