Beust M, Barten M, Kreuzberg M, Krygier-Stojałowska A, Rohde E
Zentralbl Allg Pathol. 1986;131(6):517-21.
Cytologic slides from 11 women with clinical, cytological and histological signs of a papillomavirus infection of the cervix uteri are investigated by cytophotometry and cytomorphometry. The mean values of DNA content, chromatin density, nuclear area and nuclear circumference of koilocytes were notably higher than for atypical or normal squamous cells. In those patients with concurrent cervical intraepithelial neoplasia the DNA content of koilocytes was inversely related to the degree of atypia. Squamous cells with HPV-induced lesions can be characterized by cytophotometry and cytomorphometry as a distinct cell population forming a continuum with the preneoplastic epithelium.
对11名患有子宫颈乳头瘤病毒感染临床、细胞学和组织学体征的女性的细胞学涂片进行细胞光度测定和细胞形态测定研究。挖空细胞的DNA含量、染色质密度、核面积和核周长的平均值显著高于非典型或正常鳞状细胞。在同时患有宫颈上皮内瘤变的患者中，挖空细胞的DNA含量与非典型程度呈负相关。具有人乳头瘤病毒诱导病变的鳞状细胞可通过细胞光度测定和细胞形态测定表征为与肿瘤前上皮形成连续体的独特细胞群。
