内分泌功能与血红蛋白病：镰状细胞病患儿甲状腺功能的生化评估
Endocrine function and haemoglobinopathies: biochemical assessment of thyroid function in children with sickle-cell disease.
作者信息
Lukanmbi F A, Adeyokunnu A A, Osifo B O, Bolodeoku J O, Dada O A
出版信息
Afr J Med Med Sci. 1986 Mar-Jun;15(1-2):25-8.
Thyroid function was assessed in ninety children with homozygous sickle-cell disease (haemoglobin genotype SS) in forty-five children with heterozygous sickle-cell trait (AS) and in 162 control children with haemoglobin genotype AA. Serum levels of thyroxine, the in vitro triiodothyronine resin uptake and the calculated index of 'free thyroxine' were not significantly different in the three groups. The distribution of individual thyrotropin (TSH) values showed that only 11% of the HbSS subjects had values below the 95% confidence limits for the HbAA controls. However, the mean level of TSH was significantly lower in the HbSS than the other two groups of children.
对90名纯合子镰状细胞病（血红蛋白基因型SS）儿童、45名杂合子镰状细胞性状（AS）儿童以及162名血红蛋白基因型AA的对照儿童进行了甲状腺功能评估。三组儿童的血清甲状腺素水平、体外三碘甲状腺原氨酸树脂摄取率以及计算得出的“游离甲状腺素”指数并无显著差异。促甲状腺激素（TSH）个体值的分布表明，只有11%的HbSS受试者的值低于HbAA对照的95%置信限。然而，HbSS组儿童的TSH平均水平显著低于其他两组儿童。
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