多粘菌素B九肽的体外细胞毒性和抗菌活性
In vitro cytotoxicity and antibiotic activity of polymyxin B nonapeptide.
作者信息
Duwe A K, Rupar C A, Horsman G B, Vas S I
出版信息
Antimicrob Agents Chemother. 1986 Aug;30(2):340-1. doi: 10.1128/AAC.30.2.340.
Abstract
Polymyxin B nonapeptide, prepared by enzymic removal of the fatty acyl diaminobutyric acid side chain from polymyxin B, was about 100-fold less toxic to K562 cells than polymyxin B. MICs of polymyxin B nonapeptide against a test panel of bacteria were 2- to 64-fold lower than those of polymyxin B.
摘要
通过酶法去除多粘菌素B的脂肪酰二氨基丁酸侧链制备的多粘菌素B九肽，对K562细胞的毒性比多粘菌素B低约100倍。多粘菌素B九肽对一组测试细菌的最低抑菌浓度比多粘菌素B低2至64倍。
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本文引用的文献
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Susceptibility of gram-negative bacteria to polymyxin B nonapeptide.革兰氏阴性菌对多粘菌素B九肽的敏感性。
Antimicrob Agents Chemother. 1984 Jun;25(6):701-5. doi: 10.1128/AAC.25.6.701.
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