声辐射力脉冲成像技术联合模拟急性尿路梗阻的离体猪肾模型实验研究。
ARFI shear-wave elastography with simulation of acute urinary tract obstruction in an ex vivo porcine kidney model.
机构信息
Division of Pediatric Radiology, Clinic of Diagnostic and Interventional Radiology University of Heidelberg School of Medicine, Heidelberg, Germany.
Department of Visceral and Transplantation Surgery , University of Heidelberg School of Medicine, Heidelberg, Germany.
出版信息
Diagn Interv Radiol. 2018 Sep;24(5):308-315. doi: 10.5152/dir.2018.17353.
METHODS
A total of 20 heparinized pig kidneys were investigated at 10 intrapelvic hydrostatic pressure steps (0-90 mmHg). SWE (ARFI; Virtual TouchTM IQ, Siemens) measurements were taken at three different measuring regions and in two measuring sequences using a linear ultrasonography probe (9L4, Siemens). Median values of 10 shear-wave speed (SWS) measurements were calculated for each pressure step. Logarithmic transformed median SWS values were analyzed in a linear mixed model.
RESULTS
SWS increased significantly with increasing intrapelvic pressure. Median SWS for all kidneys in both measuring sequences and all measuring regions was 1.47 m/s (interquartile range [IQR], 0.38 m/s) at 0 mmHg, 1.94 m/s (IQR, 0.42 m/s) at 30 mmHg, 2.07 m/s (IQR, 0.43 m/s) at 60 mmHg, 2.24 m/s (IQR, 0.49 m/s) at 90 mmHg. The correlation between pelvic pressure increase and median SWS values for the central parenchyma was significantly higher compared with the peripheral parenchyma.
CONCLUSION
Acutely increased renal pelvic pressure correlates with increasing SWS values in ARFI elastography in an ex vivo porcine kidney model.
方法
共对 20 个肝素化猪肾进行了 10 个肾盂静水压力步骤（0-90mmHg）的研究。在三个不同的测量区域和两种测量序列中使用线性超声探头（9L4，西门子）进行 SWE（ARFI；Virtual TouchTM IQ，西门子）测量。计算了每个压力步的 10 次剪切波速度（SWS）测量的中位数。对数转换后的中位数 SWS 值在线性混合模型中进行分析。
结果
SWS 随肾盂内压力的增加而显著增加。在两种测量序列和所有测量区域中，所有肾脏的中位 SWS 在 0mmHg 时为 1.47m/s（四分位距[IQR]，0.38m/s），在 30mmHg 时为 1.94m/s（IQR，0.42m/s），在 60mmHg 时为 2.07m/s（IQR，0.43m/s），在 90mmHg 时为 2.24m/s（IQR，0.49m/s）。与外周实质相比，中央实质的骨盆压力增加与中位 SWS 值之间的相关性明显更高。
结论
在体外猪肾模型中，急性增加的肾盂压力与 ARFI 弹性成像中的 SWS 值增加相关。
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