Hu Yahui, Wu Jing, Li Sha, Zhao Xiaoxiao
Department of Nuclear Medicine, Zhengzhou Central Hospital Affiliated to Zhengzhou University, Zhengzhou, Henan 450000, P.R. China.
Oncol Lett. 2018 Oct;16(4):4297-4302. doi: 10.3892/ol.2018.9144. Epub 2018 Jul 12.
This study aimed to investigate the correlation between CT features and liver function and p53 expression in hepatitis, cirrhosis and hepatocellular carcinoma (HCC). Forty patients with HCC, 30 patients with cirrhosis and 30 patients with chronic hepatitis were enrolled between December, 2015 and December, 2016. At the same time, normal liver tissues collected from 30 patients with hepatic hemangioma were used as the normal control group. All the patients were scanned by CT. Average body surface area, left outer lobe and caudate lobe volume, and the proportions of left outer lobe and caudate lobe to the whole liver were calculated. Biochemical indexes of liver function were determined. The pathological tissues of all the subjects were analyzed. Compared with the control group, total liver volume of the HCC group was significantly reduced (P<0.05). Compared with the HCC group, the volume of the left outer lobe increased in the hepatitis group and the cirrhosis group. Compared with control group, caudate lobe volume increased significantly in the hepatitis group (P<0.05). Compared with the control group, the volume of the left outer lobe and the proportion of caudate lobe to the whole liver volume was significantly increased in all three groups (P<0.05). Liver function-related indicators in the HCC and cirrhosis groups were significantly different from those in the control group (P<0.05). The expression level of p53 in HCC was significantly higher than that in the control group (P<0.05). The accuracy of diagnosis by using both p53 and CT was higher than the use of p53 or CT alone. CT can accurately measure the volume of each lobe of the liver, and p53 has important clinical values in the diagnosis of liver diseases. Thus, the reasonable combination of the two can effectively improve the diagnostic accuracy.
本研究旨在探讨肝炎、肝硬化及肝细胞癌（HCC）患者CT特征与肝功能及p53表达之间的相关性。2015年12月至2016年12月期间，纳入40例HCC患者、30例肝硬化患者及30例慢性肝炎患者。同时，选取30例肝血管瘤患者的正常肝组织作为正常对照组。所有患者均接受CT扫描。计算平均体表面积、左外叶及尾状叶体积，以及左外叶和尾状叶占全肝的比例。测定肝功能生化指标。对所有受试者的病理组织进行分析。与对照组相比，HCC组全肝体积显著减小（P<0.05）。与HCC组相比，肝炎组和肝硬化组左外叶体积增大。与对照组相比，肝炎组尾状叶体积显著增大（P<0.05）。与对照组相比，三组患者左外叶体积及尾状叶占全肝体积的比例均显著增加（P<0.05）。HCC组和肝硬化组肝功能相关指标与对照组相比差异有统计学意义（P<0.05）。HCC组p53表达水平显著高于对照组（P<0.05）。联合使用p53和CT诊断的准确性高于单独使用p53或CT。CT能准确测量肝脏各叶体积，p53在肝脏疾病诊断中具有重要临床价值。因此，两者合理联合可有效提高诊断准确性。
