脊髓祖细胞负载桥支持脊髓损伤后更早的轴突再生。
Spinal Progenitor-Laden Bridges Support Earlier Axon Regeneration Following Spinal Cord Injury.
机构信息
1 Department of Biomedical Engineering, University of Michigan , Ann Arbor, Michigan.
2 Institute for Memory Impairments and Neurological Disorders (iMIND), University of California , Irvine, California.
出版信息
Tissue Eng Part A. 2018 Nov;24(21-22):1588-1602. doi: 10.1089/ten.TEA.2018.0053. Epub 2018 Oct 19.
Abstract
Spinal cord injury (SCI) results in loss of tissue innervation below the injury. Spinal progenitors have a greater ability to repair the damage and can be injected into the injury, but their regenerative potential is hampered by their poor survival after transplantation. Biomaterials can create a cell delivery platform and generate a more hospitable microenvironment for the progenitors within the injury. In this work, polymeric bridges are used to deliver embryonic spinal progenitors to the injury, resulting in increased progenitor survival and subsequent regeneration and functional recovery, thus demonstrating the importance of combined therapeutic approaches for SCI.
摘要
脊髓损伤 (SCI) 导致损伤以下组织失去神经支配。脊髓祖细胞具有更强的修复损伤的能力，可以注射到损伤部位，但它们的再生潜力受到移植后存活率低的限制。生物材料可以创建一个细胞输送平台，并在损伤部位为祖细胞生成更适宜的微环境。在这项工作中，聚合物桥用于将胚胎脊髓祖细胞递送到损伤部位，从而增加祖细胞的存活率，并随后促进再生和功能恢复，这表明联合治疗方法对 SCI 很重要。
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