1 Department of Clinical Neurosciences, at Cumming school of Medicine, University of Calgary, Alberta, Canada.
2 Department of Radiology at Cumming school of Medicine, University of Calgary, Alberta, Canada.
J Cereb Blood Flow Metab. 2019 Jan;39(1):182-183. doi: 10.1177/0271678X18800274. Epub 2018 Sep 14.
Selective brain cooling is a promising advent for reducing final infarct volume and improving outcomes in ischemic stroke victims. Despite the robust body of evidence from animal studies, evidence supporting the use of selective hypothermia in stroke patients is lacking. A recent study provided promising results on the safety and possible efficacy of selective brain hypothermia via intraarterial infusion of cooled saline. Better understanding of the patients' population that may attain benefit from this approach will be informative. Details of infarct progression using perfusion imaging will also help understand the mechanism of effect of selective hypothermia to inform future trials.
选择性脑冷却有望减少缺血性脑卒中患者的最终梗死体积，改善预后。尽管动物研究提供了大量证据，但缺乏支持在脑卒中患者中使用选择性低温治疗的证据。最近的一项研究通过动脉内输注冷却盐水为选择性脑低温的安全性和可能的疗效提供了有希望的结果。更好地了解可能从这种方法中获益的患者人群将具有启发性。使用灌注成像评估梗死进展的详细信息也有助于了解选择性低温治疗的作用机制，为未来的试验提供信息。
