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1
Relationships between antibodies to native DNA and glomerulonephritis in systemic lupus erythematosus.系统性红斑狼疮中抗天然DNA抗体与肾小球肾炎的关系。
Clin Exp Immunol. 1977 Jun;28(3):426-32.
2
Disease activity in the nephritis of systemic lupus erythematosus in relation to serum complement concentrations. DNA-binding capacity and precipitating anti-DNA antibody.系统性红斑狼疮肾炎的疾病活动与血清补体浓度、DNA结合能力及沉淀性抗DNA抗体的关系。
Clin Exp Immunol. 1976 Sep;25(3):418-27.
3
Avidity of anti-DNA antibodies in serum and IgG glomerular eluates from patients with systemic lupus erythematosus. Association of high avidity antinative DNA antibody with glomerulonephritis.系统性红斑狼疮患者血清及IgG肾小球洗脱物中抗DNA抗体的亲和力。高亲和力抗天然DNA抗体与肾小球肾炎的关联。
J Clin Invest. 1977 Jan;59(1):90-6. doi: 10.1172/JCI108626.
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The immunoglobulin class of anti-DNA antibodies: detection by a fluorometric immunoassay: clinical and pathological correlations in SLE.抗DNA抗体的免疫球蛋白类别：通过荧光免疫测定法进行检测：系统性红斑狼疮中的临床与病理相关性
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[Serum anti-dsDNA antibodies in lupus nephritis].[狼疮性肾炎中的血清抗双链DNA抗体]
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6
Immunochemical characteristics of antibodies to DNA in patients with active systemic lupus erythematosus.活动性系统性红斑狼疮患者抗DNA抗体的免疫化学特征
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Late onset systemic lupus erythematosus and lupus-like disease in patients with apparent idiopathic glomerulonephritis.隐匿性特发性肾小球肾炎患者中的迟发性系统性红斑狼疮及狼疮样疾病
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Complement fixing antibodies to DS-DNA in systemic lupus erythematosus: a study using the immunofluorescent Crithidia luciliae method.系统性红斑狼疮中针对双链DNA的补体结合抗体：一项使用免疫荧光法检测克氏锥虫的研究
J Rheumatol. 1979 Jul-Aug;6(4):389-96.
10
Immunochemical demonstration of cryoprecipitable anti-native DNA antibody and DNA in the serum of patients with glomerulonephritis.免疫化学法证实肾小球肾炎患者血清中存在可冷沉淀的抗天然DNA抗体及DNA 。
J Immunol. 1980 Jan;124(1):127-33.

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Arthritis Res Ther. 2009;11(3):R87. doi: 10.1186/ar2725. Epub 2009 Jun 10.
2
Significance of enzyme linked immunosorbent assay (ELISA) for antibodies to double stranded and single stranded DNA in patients with lupus nephritis: correlation with severity of renal histology.酶联免疫吸附测定（ELISA）检测狼疮性肾炎患者抗双链和单链DNA抗体的意义：与肾脏组织学严重程度的相关性
Ann Rheum Dis. 1993 Jan;52(1):14-20. doi: 10.1136/ard.52.1.14.
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Significance of anti-entactin antibodies in patients with systemic lupus erythematosus and related disorders.抗内动蛋白抗体在系统性红斑狼疮及相关疾病患者中的意义。
Ann Rheum Dis. 1994 Oct;53(10):659-65. doi: 10.1136/ard.53.10.659.
4
Specific detection of circulating DNA:anti-DNA immune complexes in human systemic lupus erythematosus sera using murine monoclonal anti-DNA antibody.循环DNA的特异性检测：使用鼠单克隆抗DNA抗体检测人类系统性红斑狼疮血清中的抗DNA免疫复合物。
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Clinical significance of antibodies to double stranded DNA (dsDNA) for systemic lupus erythematosus (SLE).抗双链DNA（dsDNA）抗体对系统性红斑狼疮（SLE）的临床意义。
Clin Rheumatol. 1987 Jun;6 Suppl 1:56-73. doi: 10.1007/BF02200721.
6
Low avidity antibodies to double stranded DNA in systemic lupus erythematosus: a longitudinal study of their clinical significance.系统性红斑狼疮中双链DNA低亲和力抗体：其临床意义的纵向研究
Ann Rheum Dis. 1989 Aug;48(8):677-82. doi: 10.1136/ard.48.8.677.
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Autoantibodies against neutrophil cytoplasm components in systemic lupus erythematosus and in hydralazine-induced lupus.系统性红斑狼疮及肼苯哒嗪诱导性狼疮中针对中性粒细胞胞浆成分的自身抗体。
Clin Exp Immunol. 1990 Sep;81(3):380-3. doi: 10.1111/j.1365-2249.1990.tb05342.x.
8
Diversity and origin of rheumatologic autoantibodies.风湿性自身抗体的多样性与起源
Clin Microbiol Rev. 1991 Jul;4(3):256-69. doi: 10.1128/CMR.4.3.256.
9
DNA binding activity of serum from patients with systemic lupus erythematosus.系统性红斑狼疮患者血清的DNA结合活性
Clin Exp Immunol. 1979 Mar;35(3):356-63.

本文引用的文献

1
A quantitative immunochemical measure of the primary interaction between I BSA and antibody.一种对牛血清白蛋白（BSA）与抗体之间主要相互作用的定量免疫化学测定方法。
J Infect Dis. 1958 Nov-Dec;103(3):239-62. doi: 10.1093/infdis/103.3.239.
2
Measurement of serum DNA-binding activity in systemic lupus erythematosus.系统性红斑狼疮患者血清DNA结合活性的测定
N Engl J Med. 1969 Sep 25;281(13):701-5. doi: 10.1056/NEJM196909252811304.
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The pathogenesis of glomerulonephritis.肾小球肾炎的发病机制。
Am J Med. 1968 Apr;44(4):493-8. doi: 10.1016/0002-9343(68)90050-8.
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The immunopathological significance of the heterogeneity of antibody affinity.抗体亲和力异质性的免疫病理学意义。
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5
The use of ammonium sulphate globulin precipitation for determination of affinity of anti-protein antibodies in mouse serum.使用硫酸铵球蛋白沉淀法测定小鼠血清中抗蛋白抗体的亲和力。
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6
Immunologic factors and clinical activity in systemic lupus erythematosus.系统性红斑狼疮中的免疫因素与临床活动
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7
Qualitative characteristics of anti-DNA antibodies in lupus nephritis.狼疮性肾炎中抗DNA抗体的定性特征。
Arthritis Rheum. 1974 Nov-Dec;17(6):947-54. doi: 10.1002/art.1780170605.
8
Immunological studies concerning the nephritis of systemic lupus erythematosus.关于系统性红斑狼疮肾炎的免疫学研究。
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9
Precipitating antibody to D.N.A. detected by two-stage electroimmunodiffusion. Study in S.L.E. and in rheumatoid arthritis.通过两阶段电免疫扩散法检测抗DNA沉淀抗体。在系统性红斑狼疮和类风湿性关节炎中的研究。
Lancet. 1973 Oct 20;2(7834):883-5. doi: 10.1016/s0140-6736(73)92008-4.
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Significance of anti-D.N.A. antibodies in systemic lupus erythematosus.抗DNA抗体在系统性红斑狼疮中的意义。
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系统性红斑狼疮中抗天然DNA抗体与肾小球肾炎的关系。

Relationships between antibodies to native DNA and glomerulonephritis in systemic lupus erythematosus.

作者信息

Tron F, Bach J F

出版信息

Clin Exp Immunol. 1977 Jun;28(3):426-32.

PMID:302165
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1541012/
Abstract

Anti-native DNA antibodies have been evaluated in forty-six lupus patients' sera for antigen-binding capacity, affinity and precipitating activity. Diffuse proliferative glomerulonephritis was significantly correlated with the presence of high serum level of free anti-native DNA antibodies. Weak affinities were more often found in patients with than without glomerular changes but several patients had high-affinity anti-DNA antibodies and severe glomerulonephritis. No correlation was found between anti-DNA antibody-precipitating activity and renal lesions.

摘要

已对46例狼疮患者血清中的抗天然DNA抗体进行了抗原结合能力、亲和力和沉淀活性评估。弥漫性增殖性肾小球肾炎与血清中高水平游离抗天然DNA抗体的存在显著相关。与无肾小球改变的患者相比，有肾小球改变的患者更常出现弱亲和力，但也有一些患者具有高亲和力抗DNA抗体且患有严重的肾小球肾炎。未发现抗DNA抗体沉淀活性与肾脏病变之间存在相关性。