系统性红斑狼疮中抗天然DNA抗体与肾小球肾炎的关系。
Relationships between antibodies to native DNA and glomerulonephritis in systemic lupus erythematosus.
作者信息
Tron F, Bach J F
出版信息
Clin Exp Immunol. 1977 Jun;28(3):426-32.
Abstract
Anti-native DNA antibodies have been evaluated in forty-six lupus patients' sera for antigen-binding capacity, affinity and precipitating activity. Diffuse proliferative glomerulonephritis was significantly correlated with the presence of high serum level of free anti-native DNA antibodies. Weak affinities were more often found in patients with than without glomerular changes but several patients had high-affinity anti-DNA antibodies and severe glomerulonephritis. No correlation was found between anti-DNA antibody-precipitating activity and renal lesions.
摘要
已对46例狼疮患者血清中的抗天然DNA抗体进行了抗原结合能力、亲和力和沉淀活性评估。弥漫性增殖性肾小球肾炎与血清中高水平游离抗天然DNA抗体的存在显著相关。与无肾小球改变的患者相比，有肾小球改变的患者更常出现弱亲和力，但也有一些患者具有高亲和力抗DNA抗体且患有严重的肾小球肾炎。未发现抗DNA抗体沉淀活性与肾脏病变之间存在相关性。
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