Perez J, Zucchi I, Maggi A
J Neurochem. 1986 Dec;47(6):1798-803. doi: 10.1111/j.1471-4159.1986.tb13091.x.
Administration of estradiol benzoate to gonadectomized female rats results in up-regulation of CNS gamma-aminobutyric acid (GABA) receptors. The increase of [3H]muscimol binding activity is observed in six of the seven brain areas examined. The same treatment, performed in castrated male or androgenized female rats, induced an increase of [3H]muscimol binding only in the striatum. Evidence is provided suggesting that the dimorphic sensitivity of GABA receptor is not correlated with the difference in spontaneous motor activity reported between male and female rats.
给去性腺的雌性大鼠注射苯甲酸雌二醇会导致中枢神经系统γ-氨基丁酸（GABA）受体上调。在所检测的七个脑区中的六个中观察到了[³H]蝇蕈醇结合活性的增加。在去势雄性大鼠或雄激素化雌性大鼠中进行相同处理，仅在纹状体中诱导[³H]蝇蕈醇结合增加。有证据表明，GABA受体的两性敏感性差异与雄性和雌性大鼠之间报道的自发运动活动差异无关。
