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大鼠脑中的孕酮和雌激素：对γ-氨基丁酸（GABA）受体活性的调节

Progesterone and estrogens in rat brain: modulation of GABA (gamma-aminobutyric acid) receptor activity.

作者信息

Maggi A, Perez J

出版信息

Eur J Pharmacol. 1984 Aug 3;103(1-2):165-8. doi: 10.1016/0014-2999(84)90205-x.

DOI:10.1016/0014-2999(84)90205-x
PMID:6090170
Abstract

Our data indicate that estrogens and progesterone can regulate the number of GABA receptors (as detected by [3H]muscimol binding assay) in rat brain. Both hormones act in selected areas. The extent of the effect (up to 160% increase) and the number of areas responsive suggest that sex hormones may play a very important role in the regulation of the functions of GABAergic transmission in the central nervous system.

摘要

我们的数据表明，雌激素和孕酮可调节大鼠脑中GABA受体的数量（通过[3H]蝇蕈醇结合试验检测）。两种激素均在特定区域起作用。作用程度（增加高达160%）和有反应的区域数量表明，性激素可能在中枢神经系统中GABA能传递功能的调节中发挥非常重要的作用。

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1
Progesterone and estrogens in rat brain: modulation of GABA (gamma-aminobutyric acid) receptor activity.大鼠脑中的孕酮和雌激素：对γ-氨基丁酸（GABA）受体活性的调节
Eur J Pharmacol. 1984 Aug 3;103(1-2):165-8. doi: 10.1016/0014-2999(84)90205-x.
2
Sexual dimorphism in the response of the GABAergic system to estrogen administration.γ-氨基丁酸能系统对雌激素给药反应中的性别二态性。
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J Neurochem. 1986 Dec;47(6):1793-7. doi: 10.1111/j.1471-4159.1986.tb13090.x.
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Muscimol binding in rat brain: association with synaptic GABA receptors.毒蝇蕈醇在大鼠脑中的结合：与突触GABA受体的关联
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Comparison of the "specific" binding of [3H]GABA and [3H]muscimol to a particulate fraction of rat brain.[3H]γ-氨基丁酸（GABA）和[3H]蝇蕈醇与大鼠脑微粒体部分的“特异性”结合比较
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