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从致关节炎和非致关节炎细菌细胞壁制备致关节炎水溶性肽聚糖。

Preparation of arthritogenic hydrosoluble peptidoglycans from both arthritogenic and non-arthritogenic bacterial cell walls.

作者信息

Kohashi O, Pearson C M, Watanabe Y, Kotani S

出版信息

Infect Immun. 1977 Jun;16(3):861-6. doi: 10.1128/iai.16.3.861-866.1977.

Abstract

Cell wall lytic enzyme (Kyowa lytic no. 2 enzyme) liberated arthritogenic hydrosoluble peptidoglycans from both arthritogenic and non-arthritogenic bacterial cell walls. From these cell walls, mutanolysin (peptidoglycan-degrading enzyme) also liberated hydrosoluble peptidoglycans which, however, lacked arthritogenicity. Based on the chemical composition of these peptidoglycans, it was suggested that their arthritis-inducing ability depends on a relatively long chain of glycan units that consists of repeated units of N-acetylglucosaminyl-N-acetylmuramic acid. However, the glycan chain lengths on these peptidoglycans appeared to be related to their adjuvancy rather than to an antigen(s) responsible for development of arthritis in rats.

摘要

细胞壁溶解酶(协和溶解酶2号)从致关节炎和非致关节炎细菌细胞壁中释放出致关节炎的水溶性肽聚糖。从这些细胞壁中,变溶菌素(肽聚糖降解酶)也释放出水溶性肽聚糖,然而,这些肽聚糖缺乏致关节炎性。根据这些肽聚糖的化学组成,有人提出它们的关节炎诱导能力取决于由N-乙酰葡糖胺基-N-乙酰胞壁酸重复单元组成的相对长链的聚糖单元。然而,这些肽聚糖上的聚糖链长度似乎与其佐剂性有关,而不是与大鼠关节炎发生所涉及的抗原有关。

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Adjuvant arthritis in mice and hamsters.
Acta Rheumatol Scand. 1971;17(1):31-4. doi: 10.3109/rhe1.1971.17.issue-1-4.05.

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