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短暂性大脑后动脉病变:1例与肠道病毒相关的罕见病例

Transient posterior cerebral arteriopathy: An unusual case enterovirus-related.

作者信息

Piccolo Benedetta, Barsacchi Marina, Greco Francesca, Cerasti Davide, Ormitti Francesca, Pisani Francesco

机构信息

Child Neuropsychiatry Unit, Mother and Child Department, University-Hospital of Parma, Parma, Italy.

Child Neuropsychiatry Unit, Medicine and Surgery Department, University of Parma, Parma, Italy.

出版信息

Brain Dev. 2019 Feb;41(2):214-216. doi: 10.1016/j.braindev.2018.09.002. Epub 2018 Sep 14.

DOI:10.1016/j.braindev.2018.09.002
PMID:30224162
Abstract

Transient Cerebral Arteriopathy (TCA) is one of the main causes of childhood stroke. Here we present an unusual case of Arterial Ischemic Stroke (AIS) caused by a TCA of posterior flow and originally located in the right thalamus. The detection of enterovirus in the cerebrospinal fluid allowed us to suppose a probable post infectious etiology. The course of symptoms was self-limited and the child had a complete clinical recovery after five days. A new ischemic lesion on the antero-inferior paravermian region of the left cerebellum was revealed by a following brain Magnetic Resonance Imaging (MRI) three months later and these findings were reported by further brain MRI control performed after 15 months. Comparing follow up Magnetic Resonance Angiography (MRA) with previous High Resolution Vessel Wall Magnetic Resonance Imaging (HRMI), we found a vessel narrowing at the level of the Posterior Inferior Cerebellar Artery that might explain the arteriopathy process. In conclusion, clinical and radiological course allow us to speculate that this multifocal cerebral arteriopathy might be a transient lesion due to enterovirus infection. To our knowledge, there are only three articles describing TCA enterovirus-related, and brain MRA was performed in only one case; in addition, no one with the involvement of the posterior circulation.

摘要

短暂性脑动脉病(TCA)是儿童中风的主要原因之一。在此,我们报告一例不寻常的动脉缺血性中风(AIS)病例,其由后循环的TCA引起,最初位于右侧丘脑。脑脊液中检测到肠道病毒使我们推测可能存在感染后病因。症状过程为自限性,患儿在五天后临床完全康复。三个月后进行的脑部磁共振成像(MRI)显示左侧小脑蚓部前下区域出现新的缺血性病变,15个月后进行的进一步脑部MRI检查报告了这些发现。将随访磁共振血管造影(MRA)与先前的高分辨率血管壁磁共振成像(HRMI)进行比较,我们发现小脑后下动脉水平存在血管狭窄,这可能解释了动脉病过程。总之,临床和影像学过程使我们推测这种多灶性脑动脉病可能是由肠道病毒感染引起的短暂性病变。据我们所知,仅有三篇文章描述了与肠道病毒相关的TCA,且仅在一例中进行了脑部MRA;此外,没有后循环受累的病例。

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