Ishihara T, Matsumoto N, Yamashita Y, Takahashi M, Uchino F, Inoue M, Yano S, Tanaka H, Shinohara K, Kaneko T
Acta Pathol Jpn. 1986 Aug;36(8):1231-9. doi: 10.1111/j.1440-1827.1986.tb02844.x.
Cytoplasmic inclusions and virus-like particles are described in blast cells of peripheral blood from a 16-year-old female with acute lymphoblastic leukemia. Three kinds of inclusions were identified on electron microscopy. The first type of inclusion was single membrane-bounded vacuoles, some of which contained virus-like particles, the second was lysosome-like structures, and the third appeared to be of mitochondrial origin. Virus-like particles were round in shape and had a diameter of 26 to 58 nm. They consisted of an electron-dense outer membrane and an electron-lucent core. At the present time the exact nature and significance of these virus-like particles still remain unclear.
在一名16岁急性淋巴细胞白血病女性患者的外周血原始细胞中发现了细胞质内含物和病毒样颗粒。电子显微镜下鉴定出三种内含物。第一种内含物是单膜包被的空泡，其中一些含有病毒样颗粒；第二种是溶酶体样结构；第三种似乎起源于线粒体。病毒样颗粒呈圆形，直径为26至58纳米。它们由电子致密的外膜和电子透亮的核心组成。目前，这些病毒样颗粒的确切性质和意义仍不清楚。
