Takemori N, Saito N, Morioka M, Sakurada K, Miyazaki T
Am J Clin Pathol. 1985 Apr;83(4):527-34. doi: 10.1093/ajcp/83.4.527.
In acute lymphoblastic leukemia (ALL) of a 19-year-old woman, blast cells in the blood and bone marrow contained peculiar large cytoplasmic inclusions. The inclusions, measuring 0.5-3.5 micron in diameter, were stained with methylene blue, toluidin blue, pyronin, and periodic acid-Schiff. Activities for acid phosphatase and alpha naphthyl butyrate esterase were not detected in the inclusions. The cytochemical findings indicated that the inclusions contained basophilic material and polysaccharides and that they were not lysosomal in nature. In electron microscopy, the inclusions were membrane bound and contained densely packed microvesicles, measuring 40-70 nm in diameter; amorphous electron-dense material; and whorled membranous figures. The microvesicles often had a nucleoid-like core and resembled viruses in size and structure.
在一名19岁女性的急性淋巴细胞白血病（ALL）中，血液和骨髓中的原始细胞含有特殊的大细胞质包涵体。这些包涵体直径为0.5 - 3.5微米，用亚甲蓝、甲苯胺蓝、派洛宁和过碘酸 - 希夫试剂染色。在包涵体中未检测到酸性磷酸酶和α萘丁酸酯酶的活性。细胞化学结果表明，包涵体含有嗜碱性物质和多糖，且本质上不是溶酶体。在电子显微镜下，包涵体被膜包裹，含有紧密堆积的微泡，直径为40 - 70纳米；无定形电子致密物质；以及呈涡状的膜性结构。微泡通常有类核样核心，在大小和结构上类似于病毒。
