Komiyama A, Ogawa M, Eurenius K, Spicer S S
Arch Pathol Lab Med. 1976 Nov;100(11):590-4.
A 36-year-old man manifested the clinical signs of acute leukemia. Blast cells in the blood and bone marrow contained many large cytoplasmic inclusions. Cytochemical and ultrastructural studies indicated that the leukemic cells were of lymphocytic origin. Three kinds of inclusions were identified on electron microscopy: one type of inclusion contained virus-like particles; another resembled those in cases with hairy cell leukemia; and the third appeared to be autophagic in nature. The presence of the second type of inclusion in the blast cells and the relative chronicity of the clinical course suggest that this patient's disease is of lymphocytic origin, similar to hairy cell leukemia.
一名36岁男性表现出急性白血病的临床症状。血液和骨髓中的原始细胞含有许多大的细胞质内含物。细胞化学和超微结构研究表明，白血病细胞起源于淋巴细胞。电子显微镜下鉴定出三种内含物：一种内含物含有病毒样颗粒；另一种类似于毛细胞白血病病例中的内含物；第三种在本质上似乎是自噬性的。原始细胞中第二种内含物的存在以及临床病程的相对慢性表明，该患者的疾病起源于淋巴细胞，类似于毛细胞白血病。
