Alexander von Humboldt Tropical Medicine Institute, Department of Medicine, Universidad Peruana Cayetano Heredia, Cusco Branch, Peru.
Infectious Diseases Division, Department of Internal Medicine, University of Texas Medical Branch, Galveston, Texas.
Am J Trop Med Hyg. 2018 Nov;99(5):1180-1185. doi: 10.4269/ajtmh.18-0372.
is the most widely distributed trematode-affecting humans. The Andes Mountains are highly endemic for fascioliasis. We report results of a cross-sectional study evaluating the epidemiology of Fasciola among children in 26 agricultural communities in the Cusco region of Peru. Children 3 to 16 years old were enrolled in preschools and schools. Blood from participants was tested for complete blood counts, transaminases, and Fasciola antibodies. Stool samples were tested for Fasciola and other parasites. A total of 2,515 children were included in the analysis and the mean age was 9.6 years (±3.6). Ten percent (253) of the children had at least one positive test for Fasciola, 6% had chronic infection, and 0.4% acute infection. The rest of the subjects had only antibodies against Fasciola. The prevalence of infection varied from 0% to 20% between communities. Children with evidence of Fasciola exposure were older, lived at higher altitudes, and had a lower socioeconomic status than children without infection. The logistic regression analysis showed that children from Ancahuasi district, older children, and children with higher measures of poverty were more likely to have Fasciola exposure. Fascioliasis is common in the Cusco region and associated with poverty. However, the distribution varies markedly between communities.
是分布最广泛的影响人类的吸虫。安第斯山脉是肝片吸虫病的高度地方性流行区。我们报告了一项横断面研究的结果，该研究评估了秘鲁库斯科地区 26 个农业社区中儿童中 Fasciola 的流行病学。3 至 16 岁的儿童在幼儿园和学校入学。采集参与者的血液进行全血细胞计数、转氨酶和 Fasciola 抗体检测。粪便样本检测 Fasciola 和其他寄生虫。共有 2515 名儿童纳入分析，平均年龄为 9.6 岁（±3.6）。10%（253 名）的儿童至少有一项 Fasciola 检测呈阳性，6%的儿童有慢性感染，0.4%的儿童有急性感染。其余的受试者只有 Fasciola 的抗体。感染的患病率在社区之间从 0%到 20%不等。有 Fasciola 暴露证据的儿童年龄较大，生活在较高海拔地区，社会经济地位较低，没有感染的儿童。逻辑回归分析表明，来自安卡瓦西地区、年龄较大的儿童和贫困程度较高的儿童更有可能接触 Fasciola。肝片吸虫病在库斯科地区很常见，与贫困有关。然而，其分布在社区之间差异显著。
