Infectious Disease Division, Department of Internal Medicine, University of Texas Medical Branch, Galveston, Texas, USA.
Curr Opin Infect Dis. 2012 Oct;25(5):518-22. doi: 10.1097/QCO.0b013e3283567b7e.
This review focuses on the recent developments in the epidemiology, burden of disease, diagnostic tests, and treatment of fascioliasis.
Recent epidemiologic data suggest that either the endemic areas are expanding or disease is being recognized in areas where it was not previously observed. In addition, recent data highlight the effects of fascioliasis on childhood anemia and nutrition. Diagnosis remains problematic, but newer diagnostic tests including antibody, antigen, and DNA detection tests may facilitate earlier diagnosis. Recent studies suggest that point-of-care testing may soon be possible. Treatment with triclabendazole is effective, but resistance is emerging in livestock and may pose a threat for patients.
Fascioliasis continues to emerge as an important neglected disease, with new studies highlighting the under-recognized burden of disease. Further studies are needed on burden of disease, improved diagnosis, and alternative to triclabendazole treatment.
本文重点介绍了片形吸虫病的流行病学、疾病负担、诊断检测和治疗的最新进展。
最近的流行病学数据表明，疫区要么在扩大，要么在以前未观察到的地区发现了该病。此外，最近的数据强调了片形吸虫病对儿童贫血和营养的影响。诊断仍然存在问题，但包括抗体、抗原和 DNA 检测在内的新诊断检测方法可能有助于更早地诊断。最近的研究表明，即时检测可能很快成为可能。三氯苯达唑治疗有效，但在牲畜中出现了耐药性，可能对患者构成威胁。
片形吸虫病继续成为一种重要的被忽视疾病，新的研究强调了该病被低估的疾病负担。需要进一步研究疾病负担、改进诊断方法以及替代三氯苯达唑治疗的方法。
