Department of Chemistry , University of Rochester , Rochester , New York 14627 , United States.
J Am Chem Soc. 2018 Sep 26;140(38):11872-11883. doi: 10.1021/jacs.8b06893. Epub 2018 Sep 18.
Iron-catalyzed cross-coupling reactions have attracted significant research interest, as they offer numerous favorable features compared with cross-coupling reactions with precious metal catalysis. While this research has contributed to an empirical understanding of iron-catalyzed cross-coupling, the underlying fundamental mechanisms of reaction and structures of catalytically active species have remained poorly defined. The lack of such detail can be attributed to the difficulties associated with studying such iron-catalyzed reactions, where unstable paramagnetic intermediates abound. Recently, the combined application of physical-inorganic spectroscopic methods, concomitant organic product analysis, and air- and temperature-sensitive inorganic synthesis has yielded the most detailed insight currently available on reactivity and mechanism in iron-catalyzed cross-coupling. This Perspective highlights this approach and the limitations of the contributing techniques as well as some of the key features of the catalytic reactions studied and lessons learned.
铁催化交叉偶联反应引起了广泛的研究兴趣，因为它们与贵金属催化的交叉偶联反应相比具有许多优势。虽然这项研究对铁催化交叉偶联反应的经验理解做出了贡献，但反应的基本机制和催化活性物质的结构仍然没有得到很好的定义。缺乏这些细节可以归因于研究此类铁催化反应的困难，其中大量存在不稳定的顺磁中间体。最近，物理无机光谱方法的联合应用、伴随的有机产物分析以及对空气和温度敏感的无机合成，为目前在铁催化交叉偶联中的反应性和机制方面提供了最详细的见解。本观点强调了这种方法以及贡献技术的局限性，以及研究的催化反应的一些关键特征和经验教训。
