miR-21-5p 通过靶向 PDHA1 调节胃癌中的糖酵解和癌症进展。
miR‑21‑5p targets PDHA1 to regulate glycolysis and cancer progression in gastric cancer.
机构信息
Department of Gastrointestinal Colorectal and Anal Surgery, China‑Japan Union Hospital of Jilin University, Changchun, Jilin 130021, P.R. China.
Department of Gastrointestinal Colorectal and Anal Surgery, China‑Japan Union Hospital of Jilin University, Changchun, Jilin 130021, P.R. China.
出版信息
Oncol Rep. 2018 Nov;40(5):2955-2963. doi: 10.3892/or.2018.6695. Epub 2018 Sep 10.
Pyruvate dehydrogenase A1 (PDHA1) is a component of the pyruvate dehydrogenase enzyme complex, which links glycolysis and the tricarboxylic acid cycle, and is important for cancer metabolism shift. PDHA1 downregulation has been revealed in several types of cancer to enhance glycolysis. However, the role of PDHA1 in gastric cancer remains largely unknown. In the present study, we found that PDHA1 was significantly downregulated in gastric cancer, and associated with poor prognosis. PDHA1 downregulation promoted gastric cancer glycolysis and cancer progression. miR‑21‑5p directly targeted PDHA1 to suppress PDHA1 expression, and promote glycolysis as well as cell proliferation in gastric cancer. Moreover, miR‑21‑5p was significantly upregulated in gastric cancer and negatively associated with PDHA1 expression in gastric cancer samples. Our results indicated that miR‑21‑5p targeted PDHA1 to regulate a metabolic switch and cancer progression in gastric cancer, and reveal the potential role of the miR‑21‑5p/PDHA1 axis in gastric cancer treatment.
丙酮酸脱氢酶 A1（PDHA1）是丙酮酸脱氢酶复合物的一个组成部分，该复合物连接糖酵解和三羧酸循环，对癌症代谢转变很重要。PDHA1 的下调已在多种类型的癌症中被揭示，以增强糖酵解。然而，PDHA1 在胃癌中的作用在很大程度上仍不清楚。在本研究中，我们发现 PDHA1 在胃癌中显著下调，并与预后不良相关。PDHA1 的下调促进了胃癌的糖酵解和癌症进展。miR-21-5p 直接靶向 PDHA1 抑制 PDHA1 的表达，并促进胃癌中的糖酵解和细胞增殖。此外，miR-21-5p 在胃癌中显著上调，并与胃癌样本中 PDHA1 的表达呈负相关。我们的结果表明，miR-21-5p 通过靶向 PDHA1 来调节胃癌中的代谢转换和癌症进展，揭示了 miR-21-5p/PDHA1 轴在胃癌治疗中的潜在作用。
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