School of Public Health, Curtin University, Perth, WA 6148, Australia.
School of Public Health and Preventive Medicine, Monash University, Melbourne, VIC 3800, Australia.
Int J Environ Res Public Health. 2018 Sep 17;15(9):2026. doi: 10.3390/ijerph15092026.
Indoor air pollution is still considered one of the leading causes of morbidity and mortality worldwide. We aimed to investigate the potential association between indoor particulate matter (PM) and fasting clinic blood pressure in adult Australians. Sixty-three participants residing within the Perth metropolitan area were studied. Participants were aged between 18 and 65 years and free of major medical conditions. We conducted 24-h monitoring of residential PM concentrations, including the size fractions PM1, PM2.5, PM4, and PM10. All participants attended a clinical assessment at Curtin University following a 10⁻12 h overnight fast. In this study we found that PM1 and PM2.5 were significantly associated with heart rate: a one interquartile range (IQR) increase in PM1 or PM2.5 was associated with a 4⁻6 beats per minute (bpm) increase in heart rate. Both PM10 and total PM exposure had a significant impact on systolic blood pressure (SBP): a one IQR increase in PM10 and total PM were associated with a 10 mmHg (95% CI: 0.77⁻20.05) and 12 mmHg (2.28⁻22.43 mmHg) increase in SBP, respectively. The study findings provide additional support to the thesis that indoor air pollution is an important modifiable factor in the risk of hypertension.
室内空气污染仍被认为是全球发病率和死亡率的主要原因之一。我们旨在研究室内颗粒物（PM）与成年澳大利亚人空腹诊所血压之间的潜在关联。
研究对象为居住在珀斯大都市区内的 63 名参与者。参与者年龄在 18 至 65 岁之间，没有重大疾病。我们对住宅 PM 浓度进行了 24 小时监测，包括 PM1、PM2.5、PM4 和 PM10 等粒径。所有参与者在经过 10-12 小时的夜间禁食后，前往科廷大学进行临床评估。
在这项研究中，我们发现 PM1 和 PM2.5 与心率显著相关：PM1 或 PM2.5 每增加一个四分位距（IQR），心率就会增加 4-6 次/分钟。PM10 和总 PM 暴露都对收缩压（SBP）有显著影响：PM10 和总 PM 每增加一个 IQR，SBP 分别增加 10mmHg（95%CI：0.77-20.05）和 12mmHg（2.28-22.43mmHg）。
研究结果为室内空气污染是高血压风险的一个重要可改变因素这一论点提供了额外的支持。
