Zhang Huawei, Qian Jin, Zhao Haiping, Wang Jinda, Zhu Hang, Zhou Ying, Wang Juan, Guo Jin, Gehendra Mahara, Qiu Hongyan, Sun Zhijun, He Dian
a Department of Cardiology , Chinese PLA General Hospital , Beijing , PR China ;
b Department of Aged Cadres, Beijing Shijitan Hospital , Capital Medical University , Beijing , PR China ;
Blood Press. 2016 Jun;25(3):169-76. doi: 10.3109/08037051.2015.1111019. Epub 2015 Dec 4.
This systematic review and meta-analysis was conducted to assess the association between the level of atmospheric particulate matter (PM) and the increase in blood pressure (BP) for different exposure terms (≤ 7 vs > 7 days) and age groups (< 65 vs ≥ 65 years). Some databases were searched to investigate the association between increased atmospheric PM (diameter < 2.5 mm [PM2.5] or < 10 mm [PM10]) and BP (systolic blood pressure [SBP] and diastolic blood pressure [DBP]). Among a total of 719 identified articles, 68 were reviewed in depth, of which only 20 satisfied the inclusion criteria. A significant association was found between PM10 levels and higher BP. The β values were 0.270mmHg (95% confidence interval [CI] 0.068-0.482) for SBP and 0.215mmHg (95% CI 0.058-0.372) for DBP. These β values mean that, for every 10 mg/m(3) increase in PM10, SBP increased by 0.270mmHg and DBP by 0.215 mmHg. Subgroup analyses were conducted for different exposure terms and age groups. A positive association was seen between PM2.5 and SBP. The β value of SBP was 0.495mmHg (95% CI 0.03-0.96) with every 10 mg/m(3) increase in PM2.5. There were no significant associations in both age groups and non-older groups. There was no significant association between PM2.5 and DBP, either in the overall effect or in the subgroup effects. In conclusion, significant associations were found between higher BP and higher PM10 levels, but the association between BP and levels of PM2.5 levels was unclear.
本系统评价和荟萃分析旨在评估不同暴露时间（≤7天与>7天）和年龄组（<65岁与≥65岁）下大气颗粒物（PM）水平与血压升高（BP）之间的关联。检索了一些数据库，以研究大气中PM（直径<2.5毫米[PM2.5]或<10毫米[PM10]）增加与BP（收缩压[SBP]和舒张压[DBP]）之间的关联。在总共719篇已识别的文章中，对68篇进行了深入审查，其中只有20篇符合纳入标准。发现PM10水平与较高的BP之间存在显著关联。SBP的β值为0.270mmHg（95%置信区间[CI]0.068 - 0.482），DBP的β值为0.215mmHg（95%CI 0.058 - 0.372）。这些β值意味着，PM10每增加10mg/m³，SBP升高0.270mmHg，DBP升高0.215mmHg。对不同暴露时间和年龄组进行了亚组分析。发现PM2.5与SBP之间存在正相关。PM2.5每增加10mg/m³，SBP的β值为0.495mmHg（95%CI 0.03 - 0.96）。在老年组和非老年组中均无显著关联。在总体效应或亚组效应中，PM2.5与DBP之间也无显著关联。总之，发现较高的BP与较高的PM10水平之间存在显著关联，但BP与PM2.5水平之间的关联尚不清楚。
