Archer T, Cotic T, Järbe T U
Behav Neurosci. 1986 Oct;100(5):704-11. doi: 10.1037//0735-7044.100.5.704.
Two experiments were performed to investigate the effect of noradrenaline (NA) depletion following systemic administration of the neurotoxin N-(2-chloroethyl)-N-ethyl-2-bromobenzylamine (DSP4; 50 mg/kg, ip) on sensory preconditioning in the rat. For sensory preconditioning, a taste (saccharin, CS2) and a special type of drinking bottle (noisy bottle) were paired during Phase 1. During Phase 2, the noisy bottle (CS1) was paired with lithium chloride, and, finally, during Phase 3 the aversion to saccharin (CS2) was tested for in saccharin preference tests. The DSP4 treatment disrupted rats' ability to form sensory preconditioning, and this effect could not be explained on the basis of enhanced neophobia, stimulus generalization, or a deficit in first-order conditioning in DSP4-treated rats. These findings are closely related to these and other issues of associative learning such as contextual control of latent inhibition and extinction. The evidence from the present data suggests that NA-depleted rats fail to form associations between the CS1 and CS2 during sensory preconditioning and, as such, are consistent with other data from various compound conditioning experiments on the functional role of NA in learning and memory.
进行了两项实验，以研究全身注射神经毒素N-(2-氯乙基)-N-乙基-2-溴苄胺（DSP4；50毫克/千克，腹腔注射）导致去甲肾上腺素（NA）耗竭对大鼠感觉预适应的影响。对于感觉预适应，在第一阶段将一种味道（糖精，CS2）与一种特殊类型的饮水瓶（有噪音的瓶子）配对。在第二阶段，有噪音的瓶子（CS1）与氯化锂配对，最后，在第三阶段，通过糖精偏好测试来检测对糖精（CS2）的厌恶程度。DSP4处理破坏了大鼠形成感觉预适应的能力，并且这种效应不能基于DSP4处理的大鼠中增强的新恐惧症、刺激泛化或一级条件反射缺陷来解释。这些发现与联想学习的这些及其他问题密切相关，例如潜伏抑制和消退的情境控制。来自当前数据的证据表明，NA耗竭的大鼠在感觉预适应期间未能在CS1和CS2之间形成关联，因此，这与来自各种复合条件反射实验的关于NA在学习和记忆中的功能作用的其他数据一致。
