Division of Nephrology and Hypertension, Department of Internal Medicine, Jikei University School of Medicine, Tokyo, Japan.
Division of Diabetes, Metabolism and Endocrinology, Department of Internal Medicine, Jikei University School of Medicine, Tokyo, Japan.
Sci Rep. 2018 Sep 18;8(1):13999. doi: 10.1038/s41598-018-32432-z.
Fibroblast growth factor 23 (FGF23) is associated with cardiovascular disease and all-cause mortality in patients with diabetes mellitus. Insulin resistance has recently been reported to increase FGF23 levels, and resistin is a peptide that mainly regulates insulin resistance. However, few studies have investigated the association between FGF23 and resistin. A total of 422 patients with diabetes mellitus were recruited for this cross-sectional study to examine the association between resistin and intact FGF23. The mean ( ± standard deviation) age was 63.1 ± 11.9 years, and the median HbA1c was 6.7% (range, 6.1-7.1%). The mean estimated glomerular filtration rate (eGFR) was 66.2 ± 23.1 mL/min/m. Multiple regression analysis for resistin showed that logFGF23 (coefficient (Coef): 1.551; standard error (SE): 0.739; P = 0.036), C-peptide (Coef: 0.798; SE: 0.229; P = 0.001), ghrelin (Coef: 1.061; SE: 0.332; P = 0.001), intact parathyroid hormone (Coef: 0.022; SE: 0.099; P = 0.030), and eGFR (Coef: -0.091; SE: 0.017; P < 0.001) were all significantly associated with the resistin level. These associations were modified in patients with higher age, lower body mass index, and higher vitamin D levels. These results suggest that resistin is positively associated with serum FGF23 levels.
成纤维细胞生长因子 23（FGF23）与糖尿病患者的心血管疾病和全因死亡率相关。最近有研究报道胰岛素抵抗会增加 FGF23 水平，抵抗素是一种主要调节胰岛素抵抗的肽。然而，很少有研究调查 FGF23 与抵抗素之间的关系。本横断面研究共纳入 422 例糖尿病患者，以研究抵抗素与完整 FGF23 之间的关系。患者的平均（ ± 标准差）年龄为 63.1 ± 11.9 岁，中位糖化血红蛋白（HbA1c）为 6.7%（范围 6.1-7.1%）。平均估算肾小球滤过率（eGFR）为 66.2 ± 23.1 mL/min/m。抵抗素的多元回归分析显示，logFGF23（系数（Coef）：1.551；标准误差（SE）：0.739；P = 0.036）、C 肽（Coef：0.798；SE：0.229；P = 0.001）、ghrelin（Coef：1.061；SE：0.332；P = 0.001）、完整甲状旁腺激素（Coef：0.022；SE：0.099；P = 0.030）和 eGFR（Coef：-0.091；SE：0.017；P < 0.001）均与抵抗素水平显著相关。这些关联在年龄较高、体重指数较低和维生素 D 水平较高的患者中有所改变。这些结果表明，抵抗素与血清 FGF23 水平呈正相关。
