Bauerle Kevin T, Harris Charles
Kevin T. Bauerle, MD, PhD, is a Clinical Fellow, Division of Endocrinology, Metabolism, and Lipid Research, Department of Medicine, Washington University School of Medicine, St. Louis.
Charles Harris, MD, PhD, is an Assistant Professor, Division of Endocrinology, Metabolism, and Lipid Research, Department of Medicine, Washington University School of Medicine, St. Louis.
Mo Med. 2016 Sep-Oct;113(5):378-383.
Glucocorticoids (GCs), stress hormones produced by the adrenal gland, are involved in many pathways in physiology and metabolism including glucose homeostasis and inflammation. Excess GC signaling results in Cushing's syndrome and possibly metabolic syndrome. Diabetes, central adiposity, and hyperlipidemia are components of both syndromes. Here, we discuss the mechanisms of GC action, clinical syndromes of GC excess, modulation of glucose homeostasis by GCs, and future treatments for diabetes based on GC signaling.
糖皮质激素（GCs）是由肾上腺产生的应激激素，参与生理和代谢的许多途径，包括葡萄糖稳态和炎症。过量的GC信号传导会导致库欣综合征，并可能引发代谢综合征。糖尿病、中心性肥胖和高脂血症是这两种综合征的组成部分。在此，我们讨论GC的作用机制、GC过量的临床综合征、GC对葡萄糖稳态的调节以及基于GC信号传导的糖尿病未来治疗方法。
