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通过双重免疫染色观察发现，在培养皿中的牛骨膜上，FBXW2与骨钙素共定位。

FBXW2 localizes with osteocalcin in bovine periosteum on culture dishes as visualized by double immunostaining.

作者信息

Akiyama Mari

机构信息

Department of Biomaterials, Osaka Dental University, 8-1, Kuzuhahanozono-cho, Hirakata-shi, Osaka 573-1121, Japan.

出版信息

Heliyon. 2018 Sep 14;4(9):e00782. doi: 10.1016/j.heliyon.2018.e00782. eCollection 2018 Sep.

DOI:10.1016/j.heliyon.2018.e00782
PMID:30229138
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6141272/
Abstract

Osteocalcin (OC) is a well-known protein related to bone, however, the role of F-box and WD-40 domain-containing protein 2 (FBXW2) in bone remains unclear. In 2016, the presence of FBXW2 in bovine periosteum was reported. In this study, double immunostaining was used to investigate the relationship between OC and FBXW2. FBXW2 showed tubular structures, and OC showed a similar localization pattern as FBXW2. Double immunostaining findings suggested that FBXW2 tubes were coated with OC. To the author's knowledge, this is the first study to reveal the interaction between OC and FBXW2.

摘要

骨钙素（OC）是一种与骨骼相关的知名蛋白质，然而，含F-盒和WD-40结构域蛋白2（FBXW2）在骨骼中的作用仍不清楚。2016年，有报道称FBXW2存在于牛骨膜中。在本研究中，采用双重免疫染色来研究OC与FBXW2之间的关系。FBXW2呈现出管状结构，OC呈现出与FBXW2相似的定位模式。双重免疫染色结果表明，FBXW2管被OC覆盖。据作者所知，这是首次揭示OC与FBXW2之间相互作用的研究。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dbdb/6141272/657ceeca11a7/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dbdb/6141272/e25ede643987/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dbdb/6141272/f312be0373fc/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dbdb/6141272/0c7168b4844a/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dbdb/6141272/3f82056656ce/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dbdb/6141272/657ceeca11a7/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dbdb/6141272/e25ede643987/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dbdb/6141272/f312be0373fc/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dbdb/6141272/0c7168b4844a/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dbdb/6141272/3f82056656ce/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dbdb/6141272/657ceeca11a7/gr5.jpg

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2
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3
Glucose uptake inhibition decreases expressions of receptor activator of nuclear factor-kappa B ligand (RANKL) and osteocalcin in osteocytic MLO-Y4-A2 cells.
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