Illeni M T, Agazzi C, Doci R, Lombardo C, Mascheretti E, Audisio R A
Cancer Detect Prev. 1986;9(5-6):459-68.
To study human leukocyte antigens (HLA) and sister chromatid exchanges (SCE) in multiple adenomatosis coli (MAC), eight families were evaluated. Twenty-five subjects (14 affected members and 11 healthy relatives) were studied with HLA A, B, and C typing of peripheral lymphocytes and SCE count in cells that had replicated twice. The results of the present immunogenetic study, although limited to a small number of cases, suggest a correlation between HLA, SCE, and MAC. When the results of further investigations on larger series confirmed by clinical follow-up of these subjects are available, these methods might give useful information in predicting the risk of each family member to become affected by MAC and consequently develop a colorectal carcinoma.
为研究多发性结肠腺瘤病（MAC）中的人类白细胞抗原（HLA）和姐妹染色单体交换（SCE），对8个家族进行了评估。对25名受试者（14名患病成员和11名健康亲属）进行了外周淋巴细胞HLA A、B和C分型以及对已复制两次的细胞进行SCE计数。本免疫遗传学研究结果虽然限于少数病例，但提示HLA、SCE和MAC之间存在相关性。当对这些受试者进行临床随访证实的更多病例的进一步研究结果可用时，这些方法可能会为预测每个家庭成员患MAC并进而发展为结直肠癌的风险提供有用信息。
