Ma Ping, Ge Zhangwen, Feng Yi, Ou Weidong, Sun Jia, Li Kang, Xing Hui, Shao Yiming
1 Nankai University Second People's Hospital, School of Medicine, Nankai University, Tianjin, China.
2 School of Medicine, Nankai University, Tianjin, China.
AIDS Res Hum Retroviruses. 2019 Feb;35(2):205-212. doi: 10.1089/AID.2018.0177. Epub 2018 Oct 23.
In recent years, men who have sex with men (MSM) have been the most affected population with fastest growing human immunodeficiency virus (HIV) prevalence in China. In our study, a novel CRF01_AE/07_BC HIV-1 recombinant form (TJIH0069), with four unique breakpoints in the pol, vpr, and nef gene regions, was identified among MSM in Tianjin City in north China. The CRF01_AE regions (regions I, III, and V) of the recombinant are all clustered together with a previously described sequence (HQ215555), which was exclusively circulating among MSM in Shijiazhuang city of Hebei Province in north China. The CRF07_BC regions (II and IV) are clustered with BJ070032 and JX960600, which were discovered from MSM population in north China. The continuous emergence of a similar pattern of recombinant strain between the two MSM-adapted existing circulating recombinant forms (CRFs) highlights the importance to monitor potential new CRFs for early and precise control and prevention.
近年来，男男性行为者（MSM）一直是中国感染人类免疫缺陷病毒（HIV）患病率增长最快且受影响最严重的人群。在我们的研究中，在中国北方天津市的男男性行为者中鉴定出一种新型的CRF01_AE/07_BC HIV-1重组型（TJIH0069），其在pol、vpr和nef基因区域有四个独特的断点。该重组体的CRF01_AE区域（区域I、III和V）均与先前描述的序列（HQ215555）聚集在一起，该序列仅在中国北方河北省石家庄市的男男性行为者中传播。CRF07_BC区域（II和IV）与BJ070032和JX960600聚集在一起，这两个序列是在中国北方的男男性行为者群体中发现的。两种适应男男性行为者的现有流行重组型（CRF）之间持续出现类似模式的重组毒株，凸显了监测潜在新CRF以进行早期精准控制和预防的重要性。
