Dreusicke D, Schulz G E
FEBS Lett. 1986 Nov 24;208(2):301-4. doi: 10.1016/0014-5793(86)81037-7.
The conformation of the glycine-rich loop of adenylate kinase is described in detail. It forms a giant anion hole for a sulfate ion, which presumably mimicks a nucleotide phosphoryl group. This loop had been called flexible, because at pH values of 6 or below it is displaced in the crystal. In the region of this loop the adenylate kinases are probably homologous to the p21 proteins. Is is known that a mutation in this loop at residue 12 of p21 causes cell transformation and therefore cancer. Other potentially homologous proteins are indicated.
详细描述了腺苷酸激酶富含甘氨酸环的构象。它形成了一个容纳硫酸根离子的巨大阴离子孔，该硫酸根离子大概模拟了核苷酸的磷酰基。这个环过去被称为柔性环，因为在pH值为6或更低时，它在晶体中会发生位移。在这个环的区域，腺苷酸激酶可能与p21蛋白同源。已知p21蛋白中该环第12位残基的突变会导致细胞转化，进而引发癌症。还指出了其他潜在的同源蛋白。
