Tamura I, Kurimura O, Inaba Y
Jpn J Cancer Res. 1986 Oct;77(10):992-7.
For the purpose of clarifying the relation between hepatitis B virus (HBV) and hepatocellular carcinoma (HCC), a follow-up study of 1,614 HBV carriers (910 males and 704 females) was conducted at Kure National Hospital from 1970 to 1984. During the follow-up period (40.3 months on average), 247 HBV carriers died. Deaths from HCC and liver cirrhosis (LC) numbered 99 of 168 males (58.9%) and 38 of 79 females (48.2%), the chi-square test revealing no sex difference. Of 142 deaths from malignant neoplasm, HCC accounted for 52 of 96 males (54.2%) and 19 of 46 females (41.3%), the chi-square test again revealing no sex difference. The adjusted odds ratio of death from HCC among HBV carriers (1,614) with respect to HBV non-carriers (176,909) in this hospital during the study period (14-years) was 9.52 (males 7.94, females 13.39). The expected number of deaths was calculated based on the population of Hiroshima Prefecture (1978-1980) as a standard. The adjusted O/E (observed number/expected number) ratio of death from HCC was 6.66 for males and 12.13 for females, and the adjusted O/E ratio of death from LC was 5.41 for males and 11.02 for females. These findings suggest that HBV is a high risk factor of both HCC and LC, and, unlike the general population, female HBV carriers may have a rather higher risk of death from HCC and LC than male HBV carriers.
为了阐明乙型肝炎病毒（HBV）与肝细胞癌（HCC）之间的关系，1970年至1984年在吴市立医院对1614名HBV携带者（910名男性和704名女性）进行了一项随访研究。在随访期间（平均40.3个月），247名HBV携带者死亡。男性168例中有99例死于HCC和肝硬化（LC）（58.9%），女性79例中有38例（48.2%），卡方检验显示无性别差异。在142例死于恶性肿瘤的病例中，男性96例中有52例（54.2%）死于HCC，女性46例中有19例（41.3%），卡方检验再次显示无性别差异。在本医院研究期间（14年），HBV携带者（1614名）相对于非HBV携带者（176909名）因HCC死亡的校正比值比为9.52（男性为7.94，女性为13.39）。预期死亡人数以广岛县（1978 - 1980年）的人口为标准计算。男性因HCC死亡的校正观察数/预期数（O/E）比值为6.66，女性为12.13，男性因LC死亡的校正O/E比值为5.41，女性为11.02。这些发现表明，HBV是HCC和LC的高风险因素，并且与一般人群不同，女性HBV携带者死于HCC和LC的风险可能比男性HBV携带者更高。
